INT218825

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.31
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Ppp1r9a)
Ppp1r9a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 330 99.98 Very High Very High Very High
depression 234 99.24 Very High Very High Very High
Hippocampus 72 93.04 High High
addiction 12 85.56 High High
nMDA receptor 90 81.36 Quite High
Glutamate 6 78.16 Quite High
Pyramidal cell 36 73.44 Quite High
tail-flick 24 5.00 Very Low Very Low Very Low
amygdala 18 5.00 Very Low Very Low Very Low
cocaine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 540 100.00 Very High Very High Very High
Depression 234 99.24 Very High Very High Very High
Anxiety Disorder 168 79.96 Quite High
Shock 42 5.00 Very Low Very Low Very Low
Nociception 18 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Hypesthesia 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, the expression of AMPA receptor may be upregulated in neurabin KO mice.
Positive_regulation (upregulated) of neurabin KO associated with targeted disruption
1) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.12 Pain Relevance 0.27
In this report, we found that AMPA receptor-mediated EPSC is significantly increased in the neurabin KO mice.
Positive_regulation (increased) of neurabin KO associated with targeted disruption
2) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.09 Pain Relevance 0.27
Indeed, we found LTP is observed by preconditioning the KO mice with LTD induction (de-depression), suggesting that saturated EPSCs impair the LTP induction in neurabin KO mice.
Positive_regulation (induction) of neurabin KO associated with targeted disruption, depression and long-term potentiation
3) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.40 Pain Relevance 0.75
We found that paired-pulse facilitation (PPF) is significantly increased in neurabin KO mice (n?
Positive_regulation (increased) of neurabin KO associated with targeted disruption
4) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.13 Pain Relevance 0.45
Therefore, these results indicate that while electrophysiological properties of AMPA receptors remain unchanged, the AMPA receptor mediated responses are enhanced in neurabin KO mice.


Positive_regulation (enhanced) of neurabin KO associated with targeted disruption
5) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.66 Pain Relevance 0.13
Next, we examined whether pre-conditioning with LTD induction could rescue following LTP induction in neurabin KO mice.
Positive_regulation (induction) of neurabin KO associated with targeted disruption, depression and long-term potentiation
6) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.90 Pain Relevance 0.52

General Comments

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