INT218826

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.87
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmmr)
Hmmr (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 68 100.00 Very High Very High Very High
long-term potentiation 220 95.92 Very High Very High Very High
withdrawal 29 87.52 High High
Pain 16 85.08 High High
depression 156 84.08 Quite High
Hippocampus 48 81.76 Quite High
addiction 8 81.12 Quite High
nMDA receptor antagonist 8 77.96 Quite High
algogenic 1 67.28 Quite High
Glutamate 4 65.36 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 360 99.68 Very High Very High Very High
Pain 14 85.08 High High
Depression 156 84.08 Quite High
Anxiety Disorder 112 81.56 Quite High
Low Back Pain 5 63.24 Quite High
Ganglion Cysts 25 42.88 Quite Low
Nociception 27 31.44 Quite Low
Shock 28 5.00 Very Low Very Low Very Low
Nervous System Injury 15 5.00 Very Low Very Low Very Low
Neuropathic Pain 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased AMPA receptor-mediated synaptic responses may reflect the altered expression or phosphorylation of AMPA receptors in neurabin KO mice [20].
Positive_regulation (increased) of receptor-mediated associated with targeted disruption
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.64 Pain Relevance 0.08
To explore the possible mechanism for the enhanced AMPA receptor-mediated responses, biochemical experiments were conducted.
Spec (possible) Positive_regulation (enhanced) of receptor-mediated
2) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.65 Pain Relevance 0.10
In this report, we found that AMPA receptor-mediated EPSC is significantly increased in the neurabin KO mice.
Positive_regulation (increased) of receptor-mediated associated with targeted disruption
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.09 Pain Relevance 0.30
Second, since AMPA receptor-mediated EPSC is enhanced in the KO mice, the synaptic responses may have already been saturated and thus affect the following LTP induction.
Positive_regulation (enhanced) of receptor-mediated associated with targeted disruption and long-term potentiation
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.27 Pain Relevance 0.73
Takasu et al. [20] reported that CNQX-insensitive NMDA receptor-mediated Ca2+ influx in the presence of ephrinB2-EphB2 activation, which activates NMDA receptor through a Src-mediated phosphorylation.
Positive_regulation (insensitive) of receptor-mediated associated with nmda receptor
5) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2488330 Disease Relevance 0.21 Pain Relevance 0.68

General Comments

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