INT218827

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.61
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
astrocytes 3
nerve 2
neurons 1
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 20 100.00 Very High Very High Very High
Hippocampus 35 98.52 Very High Very High Very High
central sensitization 9 95.80 Very High Very High Very High
Spinal cord 13 90.88 High High
Anterior cingulate cortex 21 89.64 High High
Glutamate 42 87.76 High High
anticonvulsant 4 86.16 High High
Neuropathic pain 5 86.08 High High
long-term potentiation 171 85.04 High High
Lasting pain 26 81.40 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 198 99.68 Very High Very High Very High
Nervous System Injury 6 98.94 Very High Very High Very High
Epilepsy 4 89.16 High High
Neuropathic Pain 7 86.08 High High
Pain 38 81.40 Quite High
Nociception 32 81.24 Quite High
Depression 84 81.12 Quite High
Anxiety Disorder 495 78.08 Quite High
Inflammatory Pain 9 62.32 Quite High
Injury 14 55.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, our biochemical results showed that phosphorylation of GluR1 is significantly decreased at PKA site (Ser845), whereas phosphorylation is unaltered at the CaMKII site (Ser831).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of GluR1
1) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.85 Pain Relevance 0.14
CaMKII inhibitor, KN-93, partially blocked the phosphorylation of GluR1 at the Serine845 site, which is a PKA phosphorylation site either.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of GluR1
2) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.20 Pain Relevance 0.40
However, phosphorylation of GluR1 at CaMKII/PKC site was not altered in neurabin KO mice (n?
Neg (not) Negative_regulation (altered) of Phosphorylation (phosphorylation) of GluR1 associated with targeted disruption
3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.63 Pain Relevance 0.19
Such nerve injury triggered enhancement of postsynaptic responses and GluR1 receptor phosphorylation are abolished in AC1 knockout mice, suggesting that AC1 dependent-cAMP pathway is important.
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of GluR1 receptor in nerve associated with targeted disruption and nervous system injury
4) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.88 Pain Relevance 0.55
Proposed mechanisms of action include block of voltage-dependent Na+ and K+ channels, a positive modulatory effect on GABAA receptors, and a negative modulatory effect on AMPA/kainite-type glutamate receptor phosphorylation and ion channel conductance, and these actions may involve neurons and astrocytes [136].
Negative_regulation (effect) of Phosphorylation (phosphorylation) of glutamate receptor in astrocytes associated with glutamate receptor
5) Confidence 0.04 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.52 Pain Relevance 0.20
Proposed mechanisms of action include block of voltage-dependent Na+ and K+ channels, a positive modulatory effect on GABAA receptors, and a negative modulatory effect on AMPA/kainite-type glutamate receptor phosphorylation and ion channel conductance, and these actions may involve neurons and astrocytes [136].
Negative_regulation (effect) of in neurons Phosphorylation (phosphorylation) of glutamate receptor in astrocytes associated with glutamate receptor
6) Confidence 0.01 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.52 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox