INT218834

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ppp1cc, Gria1) transport (Gria1) mitochondrion (Ppp1cc)
endoplasmic reticulum (Gria1) carbohydrate metabolic process (Ppp1cc) cytoplasm (Ppp1cc)
Anatomy Link Frequency
spines 2
Ppp1cc (Mus musculus)
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1 74.92 Quite High
Hippocampus 12 67.56 Quite High
depression 39 39.08 Quite Low
long-term potentiation 55 38.92 Quite Low
nMDA receptor 15 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
tail-flick 4 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 90 85.16 High High
Anxiety Disorder 28 50.00 Quite Low
Depression 39 39.08 Quite Low
Shock 7 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hypesthesia 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possible explanation for the results is that neurabin-binding protein PP1 may not directly target the phosphorylated sites on GluR1 subunit in dendritic spines, but through other substrates instead.
PP1 Neg (not) Spec (may) Regulation (target) of Phosphorylation (phosphorylated) of GluR1 in spines
1) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.66 Pain Relevance 0.07

General Comments

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