INT218840

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr1) plasma membrane (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
pyramidal neurons 1
Cysltr1 (Mus musculus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 75 100.00 Very High Very High Very High
depression 70 100.00 Very High Very High Very High
Pyramidal cell 9 99.04 Very High Very High Very High
nMDA receptor 68 95.84 Very High Very High Very High
Glutamate receptor 2 81.12 Quite High
Hippocampus 24 75.28 Quite High
antagonist 5 50.00 Quite Low
spinal dorsal horn 1 25.64 Quite Low
Central grey 1 24.84 Low Low
Thalamus 1 24.00 Low Low
Disease Link Frequency Relevance Heat
Depression 70 100.00 Very High Very High Very High
Targeted Disruption 111 84.40 Quite High
Anxiety Disorder 52 50.00 Quite Low
Urological Neuroanatomy 1 24.84 Low Low
Shock 16 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Hypesthesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the inhibition of PP1 abolished LTD and activated LTP [15], [16], [37], [38].
LTD Positive_regulation (activated) of LTP associated with depression and long-term potentiation
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.42 Pain Relevance 0.30
Taken together, these results indicate that DREAM contributes selectively to pairing protocol-induced LTD but not LTP induction in the hippocampal CA1 pyramidal neurons.


LTD Neg (not) Positive_regulation (induction) of LTP in pyramidal neurons associated with depression, pyramidal cell and long-term potentiation
2) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.62 Pain Relevance 0.76

General Comments

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