INT218845

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
signal transducer activity (Cysltr1) cytoplasm (Ppp1cc) signal transduction (Cysltr1)
Ppp1cc (Mus musculus)
Cysltr1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 39 100.00 Very High Very High Very High
long-term potentiation 55 98.82 Very High Very High Very High
Hippocampus 12 83.92 Quite High
nMDA receptor 15 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
tail-flick 4 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Acute pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 39 100.00 Very High Very High Very High
Targeted Disruption 90 99.44 Very High Very High Very High
Anxiety Disorder 28 50.00 Quite Low
Shock 7 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hypesthesia 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of LTP but not LTD in the neurabin KO mice is interesting, since PP1 is critical for the induction of LTD [38] and deletion of spinophilin selectively reduced LTD but not LTP [24].
PP1 Positive_regulation (critical) of Positive_regulation (induction) of LTD associated with targeted disruption, depression and long-term potentiation
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.92 Pain Relevance 0.60

General Comments

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