INT218900

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 57 99.84 Very High Very High Very High
cINOD 2 86.56 High High
dexamethasone 43 73.12 Quite High
metalloproteinase 5 71.16 Quite High
withdrawal 7 5.00 Very Low Very Low Very Low
Cannabinoid receptor 7 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 92.96 High High
Pancreatic Cancer 20 92.76 High High
Apoptosis 114 87.44 High High
INFLAMMATION 2 86.04 High High
Cancer 137 86.00 High High
Breast Cancer 35 71.12 Quite High
Metastasis 21 56.56 Quite High
Adenocarcinoma 2 54.44 Quite High
Stress 1 49.84 Quite Low
Toxicity 2 48.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt downregulation is involved in cannabinoid antitumoral action
Regulation (involved) of Negative_regulation (downregulation) of Akt associated with cannabinoid
1) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.54 Pain Relevance 0.32
There are several mechanisms involved in the negative regulation of Akt activity by mTORC1, the effect of S6K1 on IRS-1 downstream of IGF-1 and/or insulin receptors, or other growth factors [16,17].
Regulation (involved) of Negative_regulation (regulation) of Akt
2) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955043 Disease Relevance 0.38 Pain Relevance 0
This vanadate-sensitive dual-specificity phosphatase is an immediate early gene product, normally involved in negative feedback inhibition of the MAP kinases (Slack et al. 2001, Lasa et al. 2002).
Regulation (involved) of Negative_regulation (inhibition) of kinases
3) Confidence 0.02 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.81 Pain Relevance 0.21

General Comments

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