INT218901

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoblast 1
Ptprv (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 86 98.68 Very High Very High Very High
withdrawal 14 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 220 96.60 Very High Very High Very High
Osteoporosis 54 96.28 Very High Very High Very High
Death 26 50.24 Quite High
Repression 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that the tyrosine phosphatase inhibitor, sodium orthovanadate, prevents Dex-induced inhibition of ERK activity and dysregulation of osteoblast proliferation in rats, and strongly protected against GC-osteoporosis (Hulley et al. 1998, 2002, Engelbrecht et al. 2003).
Negative_regulation (inhibitor) of tyrosine phosphatase in osteoblast associated with osteoporosis and dexamethasone
1) Confidence 0.02 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.95 Pain Relevance 0.28
Both ERK activity and proliferation are restored by co-treatment with the protein tyrosine phosphatase inhibitor, vanadate.
Negative_regulation (inhibitor) of tyrosine phosphatase
2) Confidence 0.02 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 0.78 Pain Relevance 0.08

General Comments

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