INT218919

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.61
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Xiap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 86 89.72 High High
Central nervous system 2 77.68 Quite High
Spinal cord 1 75.76 Quite High
cytokine 2 57.12 Quite High
Inflammatory response 4 53.92 Quite High
Inflammation 6 22.16 Low Low
Glutamate 8 8.04 Low Low
withdrawal 14 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 262 100.00 Very High Very High Very High
Death 80 99.28 Very High Very High Very High
Retina Disease 5 97.96 Very High Very High Very High
Optic Nerve Injuries 34 96.80 Very High Very High Very High
Injury 33 93.48 High High
Hypertension 2 91.92 High High
Glaucoma 81 89.84 High High
Eye Disease 2 83.60 Quite High
Osteoporosis 54 73.44 Quite High
Stress 5 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We assessed the transcriptional profiles of seven anti-apoptotic proteins (Bcl-2, Bcl-XL, inhibitors of apoptosis protein-1 (IAP-1), IAP-2, X-linked IAP (XIAP), Fas-associated death-domain-like IL-1?
Negative_regulation (inhibitors) of X-linked IAP associated with apoptosis and death
1) Confidence 0.32 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 1.13 Pain Relevance 0.16
We assessed the transcriptional profiles of seven anti-apoptotic proteins (Bcl-2, Bcl-XL, inhibitors of apoptosis protein-1 (IAP-1), IAP-2, X-linked IAP (XIAP), Fas-associated death-domain-like IL-1?
Negative_regulation (inhibitors) of XIAP associated with apoptosis and death
2) Confidence 0.27 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 1.13 Pain Relevance 0.16
Survival and anti-apoptotic signals [51] such as XIAP, ERK2, SOS, c-Raf-1, and YY1 are downregulated.
Negative_regulation (downregulated) of XIAP associated with apoptosis
3) Confidence 0.17 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.35 Pain Relevance 0.10
Rats were given unilateral intravitreal injections of AAV-CBA vector coding for human baculoviral IAP repeat-containing protein-4 (BIRC4), a potent caspase inhibitor.
Negative_regulation (inhibitor) of BIRC4
4) Confidence 0.12 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 1.00 Pain Relevance 0.03

General Comments

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