INT218923

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.85
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dusp1) nucleus (Dusp1) cell cycle (Dusp1)
Anatomy Link Frequency
osteoblast 1
Dusp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 4 93.16 High High
dexamethasone 86 56.72 Quite High
corticosteroid 2 8.16 Low Low
withdrawal 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 54 99.38 Very High Very High Very High
Death 26 93.08 High High
INFLAMMATION 2 92.64 High High
Apoptosis 220 90.36 High High
Breast Cancer 2 77.72 Quite High
Repression 2 76.56 Quite High
Necrosis 2 61.72 Quite High
Cancer 2 61.36 Quite High
Stress 2 56.44 Quite High
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we have previously shown that ERK activity is profoundly impaired by high-dose GC, mediated in part by rapid and sustained up-regulation of MKP-1 (Hulley et al. 1998, Engelbrecht et al. 2003).
Regulation (regulation) of MKP-1
1) Confidence 0.07 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.77 Pain Relevance 0.21
We find that GCs mediate their inhibitory effects on osteoblast proliferation in vitro via up-regulation of the vanadate-sensitive dual-specificity phosphatase, MKP-1, which profoundly represses the ERK mitogenic signalling pathway (Engelbrecht et al. 2003).
Regulation (regulation) of MKP-1 in osteoblast associated with osteoporosis
2) Confidence 0.07 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 1.08 Pain Relevance 0

General Comments

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