INT218934

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) aging (Cyp3a23/3a1)
endoplasmic reticulum (Cyp3a23/3a1) plasma membrane (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
osteoblast 1
Cyp3a23/3a1 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 43 100.00 Very High Very High Very High
withdrawal 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 27 98.76 Very High Very High Very High
Apoptosis 110 94.08 High High
Death 13 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that the tyrosine phosphatase inhibitor, sodium orthovanadate, prevents Dex-induced inhibition of ERK activity and dysregulation of osteoblast proliferation in rats, and strongly protected against GC-osteoporosis (Hulley et al. 1998, 2002, Engelbrecht et al. 2003).
Dex Negative_regulation (inhibition) of ERK in osteoblast associated with osteoporosis and dexamethasone
1) Confidence 0.01 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.95 Pain Relevance 0.28

General Comments

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