INT218936

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) nucleoplasm (Dusp1) signal transduction (Ephb1)
plasma membrane (Ephb1) nucleus (Dusp1) cell cycle (Dusp1)
Dusp1 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 90.76 High High
dexamethasone 44 86.52 High High
fifth nerve 1 86.00 High High
central sensitization 14 62.40 Quite High
cINOD 2 57.16 Quite High
trigeminal ganglion 6 50.00 Quite Low
Inflammation 14 8.08 Low Low
Calcitonin gene-related peptide 21 5.00 Very Low Very Low Very Low
Snapping jaw 16 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 110 97.24 Very High Very High Very High
INFLAMMATION 24 90.36 High High
Cognitive Disorder 2 82.28 Quite High
Repression 2 76.88 Quite High
Nociception 14 54.64 Quite High
Ganglion Cysts 6 50.00 Quite Low
Breast Cancer 1 41.72 Quite Low
Stress 1 20.44 Low Low
Osteoporosis 27 5.00 Very Low Very Low Very Low
Death 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK could be directly inactivated by the vanadate-sensitive phosphates, MKP-1, as alluded to previously (Hulley et al. 1998, Engelbrecht et al. 2003), and MKP-1-induced dephosphorylation of ERK has been shown to be essential for nitric oxide-induced apoptosis of certain cells (Pervin et al. 2003).
MKP-1 Negative_regulation (inactivated) of ERK associated with apoptosis
1) Confidence 0.03 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.67 Pain Relevance 0.16
MKP-1 is reported to dephosphorylate, and therefore, inactivate several MAP kinases including p38, JNK, and ERK, in a concentration dependent manner [33].
MKP-1 Negative_regulation (inactivate) of ERK
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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