INT218956

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ligase activity (RNF123) cytoplasm (RNF123)
RNF123 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 66.08 Quite High
Inflammation 51 50.00 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 8 99.22 Very High Very High Very High
Hypoxia 5 98.60 Very High Very High Very High
Cancer 61 97.24 Very High Very High Very High
Repression 2 71.28 Quite High
Thyroid Neoplasm 2 69.92 Quite High
Medulloblastoma 1 61.48 Quite High
Basal Cell Carcinoma 2 60.68 Quite High
Keloid Scars 103 50.00 Quite Low
INFLAMMATION 54 50.00 Quite Low
Germ Cell And Embryonal Neoplasms 1 35.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under certain conditions, to clarify the role of IL-17/IL6 axis in the regulation of KPC functions, the serum-starved cells were pretreated with different concentrations of specific neutralizing antibodies for human IL-6 or IL-17 or an isotype-matched control IgG (R & D Systems) for 1 hour followed by stimulation with IL-6 or IL-17 for 24 hours.
Regulation (regulation) of KPC
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0 Pain Relevance 0
A frequent genetic alteration in both hereditary and sporadic RCC is mutation of VHL, which encodes the targeting subunit of another ubiquitin ligase complex responsible for degrading hypoxia inducible factors, HIF1/2 alpha.
Regulation (targeting) of ubiquitin ligase associated with hypoxia and renal cancer
2) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.89 Pain Relevance 0
The effect of E2 was attributed to up-regulation of ubiquitin ligase and targeting of N-CoR for proteasomal degradation.
Regulation (regulation) of ubiquitin ligase
3) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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