INT218959

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
a band 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 64 100.00 Very High Very High Very High
agonist 41 99.90 Very High Very High Very High
analgesia 24 98.52 Very High Very High Very High
Chronic low back pain 8 91.16 High High
Opioid 113 90.16 High High
addiction 7 80.96 Quite High
withdrawal 3 77.04 Quite High
Analgesic 28 59.96 Quite High
Lasting pain 11 55.68 Quite High
tetrodotoxin 8 55.68 Quite High
Disease Link Frequency Relevance Heat
Pain 80 100.00 Very High Very High Very High
Low Back Pain 9 91.16 High High
Opiate Addiction 3 80.96 Quite High
Osteoarthritis 4 49.96 Quite Low
Vomiting 6 6.24 Low Low
Cancer 17 5.00 Very Low Very Low Very Low
Cancer Pain 14 5.00 Very Low Very Low Very Low
Hot Flashes 10 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Post Operative Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two hundred and five patients were stabilized on oxymorphone ER with a mean VAS pain intensity rating decrease from 69 at screening to 23 at completion of titration.
Negative_regulation (decrease) of Protein_catabolism (stabilized) of oxymorphone ER associated with pain
1) Confidence 0.37 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.97 Pain Relevance 1.66
There is also a band at 25 kDa (Figure 4B, Figure 4C), which likely represents a degraded fragment from ER?.
Negative_regulation (represents) of Protein_catabolism (degraded) of ER in a band
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.14
It might reflect combined effects on receptor synthesis and degradation. 4-MBC exhibits partial agonist features (Schlumpf et al. 2001a), and partial agonists can inhibit proteasomal ER degradation (Fan et al. 2004; Laios et al. 2003), but this should influence also ER-?
Negative_regulation (inhibit) of Protein_catabolism (degradation) of ER associated with agonist
3) Confidence 0.02 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0 Pain Relevance 0.10

General Comments

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