INT218968

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.15
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Gen1) nuclease activity (Gen1)
Anatomy Link Frequency
body 2
mammary gland 1
uterine 1
Gen1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 10 92.72 High High
isoflurane 5 40.48 Quite Low
Pain 5 31.56 Quite Low
withdrawal 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 30 100.00 Very High Very High Very High
Sprains And Strains 5 99.88 Very High Very High Very High
Decapitation 5 94.56 High High
Pyometra 25 78.92 Quite High
Frailty 5 78.08 Quite High
Cancer 45 71.84 Quite High
Metaplasia 15 68.64 Quite High
Hyperplasia 35 65.08 Quite High
Necrosis 15 49.76 Quite Low
Peripheral Arterial Disease 10 26.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, mammary gland proliferation was increased under both E2 and GEN.
Positive_regulation (increased) of GEN in mammary gland
1) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.12 Pain Relevance 0
GEN high increased uterine weights only around 2-fold (Figure 2).
Positive_regulation (increased) of GEN in uterine
2) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.24 Pain Relevance 0
On the basis of food intake, we estimated that the daily exposure to free E2 or GEN per animal (in milligrams per kilograms body weight) was as follows: E2 low, 0.17; E2 high, 0.7; GEN low, 5.4; GEN high, 53.


Positive_regulation (free) of GEN in body associated with body weight
3) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.25 Pain Relevance 0.09
On the basis of food intake, we estimated that the daily exposure to free E2 or GEN per animal (in milligrams per kilograms body weight) was as follows: E2 low, 0.17; E2 high, 0.7; GEN low, 5.4; GEN high, 53.


Positive_regulation (free) of GEN in body associated with body weight
4) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.24 Pain Relevance 0.08
GEN low increased epithelial height only slightly; GEN high dose, however, increased numbers of layers comparable to E2 high.
Positive_regulation (increased) of GEN
5) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.29 Pain Relevance 0

General Comments

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