INT219

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 55
Total Number 62
Disease Relevance 20.88
Pain Relevance 17.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 14
brain 4
caudate-putamen 3
substantia nigra 2
neuronal 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 2287 100.00 Very High Very High Very High
Calcitonin gene-related peptide 25 100.00 Very High Very High Very High
noradrenaline 13 99.86 Very High Very High Very High
Substantia nigra 199 99.50 Very High Very High Very High
Enkephalin 32 99.26 Very High Very High Very High
antagonist 42 98.90 Very High Very High Very High
Clonidine 25 98.80 Very High Very High Very High
Catecholamine 93 98.76 Very High Very High Very High
Morphine 24 98.28 Very High Very High Very High
agonist 168 98.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 184 99.84 Very High Very High Very High
Parkinson's Disease 1993 99.82 Very High Very High Very High
Disease 624 99.52 Very High Very High Very High
Urological Neuroanatomy 104 99.08 Very High Very High Very High
Ganglion Cysts 72 98.92 Very High Very High Very High
Drug Induced Neurotoxicity 164 96.16 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 20 96.00 Very High Very High Very High
Dystonia 5 95.68 Very High Very High Very High
Toxicity 173 94.24 High High
Targeted Disruption 293 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of mice with alpha-methyltyrosine (20 mg/kg i.p., one hour), an inhibitor of tyrosine hydroxylase, significantly decreased the activity-increasing effects of morphine.
Negative_regulation (inhibitor) of tyrosine hydroxylase associated with morphine
1) Confidence 0.59 Published 1976 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 137340 Disease Relevance 0.27 Pain Relevance 0.91
Here, we show that DADLE was able to block the protein as well as the functional loss of dopamine transporter (DAT) and tyrosine hydroxylase (TH) induced by methamphetamine.
Negative_regulation (loss) of TH associated with dopamine
2) Confidence 0.58 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.30
Blockade of dopamine transporter and tyrosine hydroxylase activity loss by [D-Ala(2), D-Leu(5)]enkephalin in methamphetamine-treated CD-1 mice.
Negative_regulation (loss) of tyrosine hydroxylase associated with dopamine and enkephalin
3) Confidence 0.58 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.43
Here, we show that DADLE was able to block the protein as well as the functional loss of dopamine transporter (DAT) and tyrosine hydroxylase (TH) induced by methamphetamine.
Negative_regulation (loss) of tyrosine hydroxylase associated with dopamine
4) Confidence 0.58 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.30
The disappearance rate of brain NA after inhibition of tyrosine hydroxylase by alpha-methyltyrosine methylester (250 mg/kg), the utilization of NA, was accelerated by morphine, whereas that of DA was not affected.
Negative_regulation (inhibition) of tyrosine hydroxylase in brain associated with dopamine, noradrenaline and morphine
5) Confidence 0.45 Published 1978 Journal J. Neural Transm. Section Abstract Doc Link 690627 Disease Relevance 0 Pain Relevance 1.60
Second, as we demonstrate in the present study, the remaining DA in all compartments is extremely sensitive to TH inhibition.
Negative_regulation (inhibition) of TH associated with dopamine
6) Confidence 0.44 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.13 Pain Relevance 0.76
Remarkably, the MPTP-induced loss of tyrosine hydroxylase immunoreactivity in nigral cell bodies was nearly completely prevented by the higher dose of sodium salicylate.
Negative_regulation (loss) of tyrosine hydroxylase associated with parkinson's disease
7) Confidence 0.42 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10543426 Disease Relevance 0.64 Pain Relevance 0.19
Clonidine suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reductions of striatal dopamine and tyrosine hydroxylase activity in mice.
Negative_regulation (reductions) of tyrosine hydroxylase associated with dopamine and clonidine
8) Confidence 0.40 Published 1995 Journal J. Neurochem. Section Title Doc Link 7616226 Disease Relevance 0.78 Pain Relevance 0.78
By contrast, exposure to MPTP induced a significant and longlasting decrease of TH mRNA in ageing mice fed with a control diet after either 7, 21 d (Figure 2A and 2C), 30 or 40 d (Figure 2A and 2D).
Negative_regulation (decrease) of TH mRNA associated with parkinson's disease and aging
9) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.58 Pain Relevance 0.12
In this study, we evaluated the effects of an alpha 2-agonist (clonidine) and an alpha 2-antagonist (yohimbine) on MPTP-induced striatal DA depletion and tyrosine hydroxylase activity reduction.
Negative_regulation (reduction) of tyrosine hydroxylase associated with parkinson's disease, dopamine, antagonist, agonist and clonidine
10) Confidence 0.39 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7616226 Disease Relevance 0.92 Pain Relevance 0.86
Thus, in a normal animal, complete depletion of striatal DA is unachievable by TH inhibition alone, and additional depletion of vesicular DA by VMAT2 inhibitors, such as reserpine is required [33,47–49].
Negative_regulation (inhibition) of TH associated with dopamine
11) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.21 Pain Relevance 0.65
Equivalent PP2A and TH protein levels were seen on immunoblots from all mice (not shown); however, significantly less TH activity was noted for mice transduced with WT-Syn or S129A compared with GFP lentiviral control mice, with a larger decrease in TH activity noted for S129A-Syn mice (Fig. 6C; p < 0.001, one-way ANOVA).
Negative_regulation (decrease) of TH
12) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.12
This reduction in TH-Ser(P)-19 in WT-Syn- and S129A-Syn-transduced SNc suggested that TH activity might also be reduced in a-Syn lentivirally transduced mice.
Negative_regulation (reduced) of TH
13) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.14
In addition, there was a central sector of nearly complete loss of TH-positive neurons in the substantia nigra para compacta and a marked depletion of TH-positive neurons in cell group A8 that, together, may have accounted for the diminution of TH-positive innervation of the striatal matrix.
Negative_regulation (depletion) of TH in neurons associated with substantia nigra
14) Confidence 0.38 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1690789 Disease Relevance 0 Pain Relevance 0.25
In addition, there was a central sector of nearly complete loss of TH-positive neurons in the substantia nigra para compacta and a marked depletion of TH-positive neurons in cell group A8 that, together, may have accounted for the diminution of TH-positive innervation of the striatal matrix.
Negative_regulation (loss) of TH in neurons associated with substantia nigra
15) Confidence 0.38 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1690789 Disease Relevance 0.05 Pain Relevance 0.26
Western blotting and enzymatic assays showed that DADLE blocked the protein loss and functional impairment of DAT and TH induced by methamphetamine.
Negative_regulation (impairment) of TH
16) Confidence 0.37 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10980266 Disease Relevance 0 Pain Relevance 0.27
While both the outer fibrous layer and the inner more cellular cambium layer of the periosteum receive an extensive innervation by calcitonin gene-related peptide (CGRP) and 200-kDa neurofilament (NF200) positive sensory fibers as well as tyrosine hydroxylase (TH) positive sympathetic fibers, there is a differential organization of sensory vs. sympathetic fibers within the periosteum.
Negative_regulation (receive) of TH in sympathetic associated with calcitonin gene-related peptide
17) Confidence 0.36 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17950532 Disease Relevance 0.38 Pain Relevance 0.37
We evaluated behavioral deficits (olfactory and motor impairment), neurodegeneration (loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra pars compacta, SNc), biochemical markers of functional impairment in the caudate-putamen (CPu) (striatal enkephalin mRNA, DA and DOPAC levels), and glial reactivity (CD11b and GFAP immunoreactivity in the SNc and CPu) at progressive time-points (after 1, 3, 7, and 10 administrations of MPTPp).
Negative_regulation (loss) of TH in caudate-putamen associated with dopamine, substantia nigra and enkephalin
18) Confidence 0.36 Published 2009 Journal Neurotox Res Section Abstract Doc Link 19526289 Disease Relevance 0.48 Pain Relevance 0.27
We evaluated behavioral deficits (olfactory and motor impairment), neurodegeneration (loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra pars compacta, SNc), biochemical markers of functional impairment in the caudate-putamen (CPu) (striatal enkephalin mRNA, DA and DOPAC levels), and glial reactivity (CD11b and GFAP immunoreactivity in the SNc and CPu) at progressive time-points (after 1, 3, 7, and 10 administrations of MPTPp).
Negative_regulation (loss) of tyrosine hydroxylase in caudate-putamen associated with dopamine, substantia nigra and enkephalin
19) Confidence 0.36 Published 2009 Journal Neurotox Res Section Abstract Doc Link 19526289 Disease Relevance 0.48 Pain Relevance 0.27
By contrast, HCT1026 significantly counteracted the loss of TH (Figure 3A and 3D)- and DAT (Figure 3E and 3H)-IF signal intensity, up to 40 dpt.
Negative_regulation (loss) of TH
20) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.77 Pain Relevance 0

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