INT21900

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 150
Total Number 153
Disease Relevance 69.47
Pain Relevance 27.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
T cell 17
DCs 15
Macrophages 9
bone marrow 8
cornea 4
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 226 100.00 Very High Very High Very High
Somatostatin 119 100.00 Very High Very High Very High
cytokine 1755 99.98 Very High Very High Very High
substance P 320 99.96 Very High Very High Very High
aspirin 493 99.84 Very High Very High Very High
mu opioid receptor 7 99.72 Very High Very High Very High
Dorsal column 1 99.72 Very High Very High Very High
Inflammation 2314 99.64 Very High Very High Very High
agonist 163 99.58 Very High Very High Very High
chemokine 618 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 1473 100.00 Very High Very High Very High
Granuloma 25 100.00 Very High Very High Very High
Decompression Sickness 16 100.00 Very High Very High Very High
Candida Infection 137 99.92 Very High Very High Very High
Targeted Disruption 238 99.76 Very High Very High Very High
Disease 1302 99.68 Very High Very High Very High
INFLAMMATION 2506 99.64 Very High Very High Very High
Dysesthesia 3 99.48 Very High Very High Very High
Cancer 1020 99.44 Very High Very High Very High
Sepsis 214 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Gene_expression (transfer) of DCs associated with agonist
1) Confidence 0.75 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.62 Pain Relevance 0.09
Evaluation of antigen-presenting activity of BMDCs
Gene_expression (presenting) of DCs
2) Confidence 0.65 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 0.38 Pain Relevance 0
These DCs were immature (major histocompatability complex class II(low)) and expressed vascular endothelial growth factor receptor 2.
Gene_expression (expressed) of DCs in DCs
3) Confidence 0.51 Published 2008 Journal FASEB J. Section Abstract Doc Link 17873101 Disease Relevance 1.41 Pain Relevance 0.40
Our results suggest that MOR is inducibly expressed on activated DCs and functionally mediates EM1-induced effects on DCs.
Gene_expression (expressed) of DCs in DCs associated with mu opioid receptor
4) Confidence 0.48 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19189219 Disease Relevance 0 Pain Relevance 0.49
Tumor cells at the periphery of HIFU-Induced thermal lesion may possess a stronger immunostimulatory property for DCs maturation
Gene_expression (maturation) of DCs associated with cancer
5) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.70 Pain Relevance 0
Indeed, histological slices from the adductor muscle confirm that the superficial tissue in the occluded limb is more vascularized than the deep tissue after 28 days, again providing evidence of the origin of higher perfusion ratios of LDF compared to DCS.

3.4 Metabolic recovery of the tissue

Gene_expression (recovery) of DCS in limb associated with deep tissue
6) Confidence 0.40 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0 Pain Relevance 0.05
These values were used as inputs for DCS fitting so that the DCS-based perfusion ratios showed in Fig. 2 only reflect changes in blood flow.
Gene_expression (fitting) of DCS in blood
7) Confidence 0.40 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0.12 Pain Relevance 0
To analyze the expression levels of co-stimulatory molecules, DCs were collected into cold PBS plus 1% dialyzed bovine serum albumin, then washed and stained on ice for 30 min with a combination of the following monoclonal antibodies: FITC-Conjugated Anti-Mouse CD11c, PE-Conjugated Anti-Mouse CD86, and PE-CY5-Conjugated Anti-Mouse CD80 (BD Biosciences Pharmingen, USA).
Spec (analyze) Gene_expression (expression) of DCs in CD86
8) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.48 Pain Relevance 0
m/min), followed by subcapsular DCs (about 2 to 3 ?
Gene_expression (followed) of DCs
9) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.13
Subtle differences in the exact duration of T cell–DC interactions might be explained by differences in the experimental set-up (oxygen perfusion versus no perfusion; different time points of analysis; differences in cell tracker dyes used), the type of cells being examined (CD4+ versus CD8+ T cells; bone marrow-derived DCs versus freshly isolated splenic DCs) or the method of detection (confocal versus two-photon microscopy with different limitation in the depths that can be analyzed).
Gene_expression (derived) of DCs in T cell
10) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
DCs in the B cell zone moved the fastest (about 4 ?
Gene_expression (moved) of DCs in B cell
11) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.13
With tDCS, cortical neurons excitability increases in the vicinity of the anodal electrode and suppressed near the cathodal electrode.
Gene_expression (electrode) of tDCS in neurons
12) Confidence 0.33 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 20096507 Disease Relevance 0.75 Pain Relevance 0.21
CSFE+ DCs are then detected after migration in the draining lymph nodes and the interaction with antigen-specific adoptively transferred T cells can be analyzed.
Gene_expression (detected) of DCs in lymph nodes
13) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0.07 Pain Relevance 0.03
When adoptively transferred, lipopolysaccharide-stimulated mature DCs were analyzed they were found to settle at the interface between the B and T cell zones and were present throughout the T cell area at 24 hours and at later time points (48 to 72 hours).
Gene_expression (transferred) of DCs in T cell
14) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.06
2 in bone marrow derived DCs.
Gene_expression (derived) of DCs in bone marrow
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.13 Pain Relevance 0.15
Furthermore, experimental animal studies have shown that DCs pulsed with collagen are able to induce autoimmune arthritis after transfer to joints [6], suggesting that DCs play an active role during the inductive phase of inflammation.
Gene_expression (pulsed) of DCs in joints associated with inflammation and arthritis
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.74 Pain Relevance 0.20
Regarding the mechanism of DC action, adoptive transfer of IL-4-expressing DCs lead to suppression of Th1-type immune responses in the lymph nodes and spleen and diminished the associated humoral immune responses.
Gene_expression (transfer) of DCs in spleen
17) Confidence 0.26 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 1.10 Pain Relevance 0.22
DCs were generated from bone marrow progenitors by standard IL-4 and GM-CSF culture and transfected on Day 6 with CD40-siRNA.
Gene_expression (transfected) of DCs in bone marrow
18) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.28 Pain Relevance 0.08
Silencing was specific in that CD 40 siRNA did not change gene expression of CD80 in DCs (Figure 1C).
Gene_expression (expression) of DCs
19) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.24 Pain Relevance 0.07
To test this hypothesis, we used CD40-silenced DCs as allostimulators in MLR.
Gene_expression (used) of DCs
20) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.26 Pain Relevance 0.06

General Comments

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