INT21901

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 10.46
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
salivary gland 2
upper 2
tears 1
uterus 1
pituitary 1
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 3 100.00 Very High Very High Very High
Nicotine 12 99.98 Very High Very High Very High
Dismenorea 7 99.64 Very High Very High Very High
metalloproteinase 9 99.32 Very High Very High Very High
qutenza 21 99.12 Very High Very High Very High
peptic ulcer disease 4 99.04 Very High Very High Very High
Hyperalgesia 14 99.00 Very High Very High Very High
antagonist 46 97.56 Very High Very High Very High
Kinase C inhibitor 2 97.44 Very High Very High Very High
tetrodotoxin 2 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 3 100.00 Very High Very High Very High
Salivary Gland Disease 8 99.84 Very High Very High Very High
Cancer 29 99.80 Very High Very High Very High
Nicotine Addiction 19 99.72 Very High Very High Very High
Dysmenorrhea 7 99.64 Very High Very High Very High
Hypomagnesemia 6 99.50 Very High Very High Very High
Disorders Of The Lacrimal System 7 99.42 Very High Very High Very High
Ulcers 15 99.12 Very High Very High Very High
Disease 10 99.10 Very High Very High Very High
Hyperalgesia 14 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Salivectomy, which decreased the luminal content of epidermal growth factor (EGF) (by about 80%), markedly attenuated this adaptation, and this was reversed by the addition of exogenous EGF.
Negative_regulation (decreased) of EGF
1) Confidence 0.58 Published 1995 Journal Scand. J. Gastroenterol. Section Body Doc Link 7701252 Disease Relevance 0.07 Pain Relevance 0
Diseases of the lacrimal gland therefore may lead to decreased concentrations of EGF in tears.
Negative_regulation (decreased) of EGF in tears associated with disorders of the lacrimal system and disease
2) Confidence 0.43 Published 1990 Journal Acta Ophthalmol (Copenh) Section Abstract Doc Link 2220366 Disease Relevance 0.59 Pain Relevance 0.07
However, whether such an action is mediated through a depression on epidermal growth factor (EGF) is undefined.
Negative_regulation (depression) of EGF associated with depression
3) Confidence 0.43 Published 2000 Journal Life Sci. Section Abstract Doc Link 11210723 Disease Relevance 0.71 Pain Relevance 0.53
ENK resulted in a decrease in the EGF content of the uterus, which was already significant after 48 h of the implantation.
Negative_regulation (decrease) of EGF in uterus
4) Confidence 0.43 Published 2000 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11021765 Disease Relevance 0 Pain Relevance 0.11
Removal of salivary glands, which reduced luminal content of EGF and DNA synthesis by about fourfold compared to rats with intact glands, produced a significant delay in healing, and this was further aggravated by capsaicin denervation.
Negative_regulation (reduced) of EGF in salivary glands associated with qutenza and salivary gland disease
5) Confidence 0.42 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.81 Pain Relevance 0.42
The concentration of receptors for EGF was significantly reduced by treatment with the bombesin/GRP antagonist RC-3095.
Negative_regulation (reduced) of EGF
6) Confidence 0.39 Published 1993 Journal Cancer Section Body Doc Link 8242552 Disease Relevance 0 Pain Relevance 0
Blockade of epidermal growth factor-induced uterine contractions by indomethacin or nordihydroguaritic acid.
Negative_regulation (Blockade) of epidermal growth factor in uterine associated with dismenorea
7) Confidence 0.37 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2506336 Disease Relevance 0.39 Pain Relevance 0.39
The protective effect of EGF was significantly inhibited by pretreatment with capsaicin desensitization, human CGRP1 antagonist hCGRP-(8-37), or N(omega)-nitro-L-arginine methyl ester (L-NAME).
Negative_regulation (inhibited) of EGF associated with qutenza and antagonist
8) Confidence 0.37 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292598 Disease Relevance 0.06 Pain Relevance 0.45
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Negative_regulation (reduce) of EGF in salivary gland associated with nicotine addiction and nicotine
9) Confidence 0.35 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.39 Pain Relevance 0.52
Although these findings suggest a possible role for EGF deficiency in the pathogenesis of peptic ulcer disease, the pathophysiological significance of our results (if any) remains to be elucidated.
Negative_regulation (deficiency) of EGF associated with peptic ulcer disease and disease
10) Confidence 0.29 Published 1990 Journal Am. J. Gastroenterol. Section Abstract Doc Link 2327382 Disease Relevance 0.77 Pain Relevance 0.17
Regardless, EGF inhibition did not improve TER in cells obtained from septic animals.


Negative_regulation (inhibition) of EGF
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.28 Pain Relevance 0.04
EGF inhibits PGE2 induced mechanical hyperalgesia
Negative_regulation (inhibits) of EGF associated with hyperalgesia
12) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.70 Pain Relevance 0.76
In chronic pancreatitis, EGF and EGF-R were significantly decreased as compared to pancreatic cancer and controls.
Negative_regulation (decreased) of EGF
13) Confidence 0.22 Published 1999 Journal Int. J. Pancreatol. Section Body Doc Link 10360220 Disease Relevance 0.11 Pain Relevance 0
ribozyme resulted in a partial decrease of the EGF-induced ERK1/2 activation, in accordance with a role of Gi.
Spec (partial) Negative_regulation (decrease) of EGF
14) Confidence 0.18 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.08 Pain Relevance 0
The number of O4 positive cells obtained in EGF alone or in combination with TGF?
Negative_regulation (obtained) of EGF
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.11
Treatment of mouse pituitary cells cultured in serum-free medium with an inhibitor of the EGF-R tyrosine kinase or with antisense TGF-?
Negative_regulation (inhibitor) of EGF-R in pituitary
16) Confidence 0.17 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.20 Pain Relevance 0
Epidermal growth factor (EGF) is produced in the salivary and Brunner's glands of the upper gastrointestinal tract, inhibits gastric acid secretion, and is a powerful mitogen.
Negative_regulation (inhibits) of EGF in upper
17) Confidence 0.13 Published 1996 Journal Helicobacter Section Abstract Doc Link 9398872 Disease Relevance 0.78 Pain Relevance 0.07
Epidermal growth factor (EGF) is produced in the salivary and Brunner's glands of the upper gastrointestinal tract, inhibits gastric acid secretion, and is a powerful mitogen.
Negative_regulation (inhibits) of Epidermal growth factor in upper
18) Confidence 0.13 Published 1996 Journal Helicobacter Section Abstract Doc Link 9398872 Disease Relevance 0.78 Pain Relevance 0.07
The effect of D-ala2-D-leu5-enkephalin was prevented by pretreatment of the cells with pertussis toxin and was not observed in non-transfected parental fibroblasts whereas the effect of epidermal growth factor was still manifest in both these situations.
Negative_regulation (effect) of epidermal growth factor in fibroblasts associated with bordatella infection and enkephalin
19) Confidence 0.11 Published 1997 Journal Cell. Signal. Section Abstract Doc Link 9376223 Disease Relevance 0.10 Pain Relevance 0.52
Interestingly, cetuximab, a drug used in treatment of certain cancers, acts an inhibitor of the EGF receptor and causes hypomagnesemia which may be due to the inhibition of EGF signaling.
Negative_regulation (inhibition) of EGF associated with hypomagnesemia and cancer
20) Confidence 0.08 Published 2007 Journal J. Nephrol. Section Abstract Doc Link 17918133 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox