INT219012

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.34
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BATF)
Anatomy Link Frequency
fat 1
cortex 1
BATF (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 90 99.24 Very High Very High Very High
Inflammation 20 98.20 Very High Very High Very High
Central nervous system 5 64.28 Quite High
alcohol 7 49.44 Quite Low
agonist 5 33.20 Quite Low
antidepressant 5 5.64 Low Low
cytokine 19 5.00 Very Low Very Low Very Low
Locus ceruleus 15 5.00 Very Low Very Low Very Low
Serotonin 15 5.00 Very Low Very Low Very Low
Raphe 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 10 99.60 Very High Very High Very High
Premenstrual Syndrome 515 99.34 Very High Very High Very High
INFLAMMATION 29 98.20 Very High Very High Very High
Insulin Resistance 18 97.64 Very High Very High Very High
Stress 20 97.48 Very High Very High Very High
Metabolic Syndrome 53 96.28 Very High Very High Very High
Disorder Of Lipid Metabolism 18 94.84 High High
Cardiovascular Disease 61 80.32 Quite High
Weight Loss 21 69.76 Quite High
Diabetes Mellitus 60 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SFA intake of the RM group was slightly elevated, relative to the PFS group.
Positive_regulation (elevated) of SFA
1) Confidence 0.05 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2174488 Disease Relevance 0.31 Pain Relevance 0
Since sleep spindles are thought to have a sleep-protecting effect via their blockage of information processing to the cortex [74], increased SFA may be the mechanism through which sleep quality is maintained at a good level despite the changing physiological and hormonal profile associated with different menstrual cycle phases.


Positive_regulation (increased) of SFA in cortex
2) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0.03
The most consistently observed menstrual cycle-related changes in the sleep profile of healthy women are a reduction of REM sleep [49, 51–53, 56], with a maintenance of homeostatic sleep mechanisms throughout the cycle [90], and a robust variation of SFA across the menstrual cycle [48, 49, 55], which increases in association with progesterone during the LP.
Positive_regulation (increases) of SFA
3) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.60 Pain Relevance 0.09
Similar to controls, PMS/PMDD women experienced a significant increase in SFA during the LP compared to the FP, though, here, a trend for increased activity in the 12-13?
Positive_regulation (increase) of SFA associated with dismenorea and premenstrual syndrome
4) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 1.23 Pain Relevance 0.58
Similarly, women with PMS/PMDD have also shown decreases in REM sleep [52, 56] and increases in SFA [55] during the LP compared to the FP.
Positive_regulation (increases) of SFA associated with dismenorea and premenstrual syndrome
5) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.62 Pain Relevance 0.15
The effects of menstrual phase on quantitative sleep EEG have been investigated by a few groups, yet results indicate a very consistent pattern of findings, making the prominent increase in SFA during the LP the most characteristic menstrual cycle associated sleep change [48, 49, 55] (Table 1).
Positive_regulation (increase) of SFA
6) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0
Increased intake of total fat, TFA, SFA, and w-6 fatty acids and refined carbohydrates, may cause insulin resistance resulting into metabolic syndrome [23, 24, 31–37].
Positive_regulation (Increased) of SFA in fat associated with metabolic syndrome and insulin resistance
7) Confidence 0.00 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.58 Pain Relevance 0.05

General Comments

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