INT219037

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
extracellular region (Bdnf) nucleolus (Creb1) nucleus (Creb1)
Creb1 (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 24 100.00 Very High Very High Very High
Pain 17 88.32 High High
Hippocampus 40 82.28 Quite High
ischemia 67 81.48 Quite High
Central nervous system 15 75.28 Quite High
spinal dorsal horn 2 72.44 Quite High
Lasting pain 11 69.68 Quite High
Spinal cord 22 65.12 Quite High
antidepressant 2 64.04 Quite High
antagonist 10 57.24 Quite High
Disease Link Frequency Relevance Heat
Pain 25 88.32 High High
Cv General 4 Under Development 59 81.48 Quite High
Cognitive Disorder 18 80.92 Quite High
Stress 10 80.88 Quite High
Nociception 27 80.04 Quite High
Death 6 65.68 Quite High
Apoptosis 5 63.92 Quite High
Targeted Disruption 9 58.92 Quite High
Hyperalgesia 4 43.24 Quite Low
Injury 2 32.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, CREB phosphorylated at serine133 (p-CREB) further induces transcription of genes containing cAMP response element (CRE) binding sites in their promoter regions [31], such as c-fos, NK-1, BDNF, and trkB [32-34].
CREB Positive_regulation (induces) of Transcription (transcription) of BDNF
1) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.40 Pain Relevance 0.49
The delayed induction of BDNF could be explained by the time needed for CREB to enhance transcription of BDNF and for its translation into mature protein.
CREB Positive_regulation (enhance) of Transcription (transcription) of BDNF associated with bdmf
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.67 Pain Relevance 0.41

General Comments

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