INT219038

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
extracellular region (Bdnf) nucleolus (Creb1) nucleus (Creb1)
Creb1 (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 22 95.52 Very High Very High Very High
Dorsal horn 11 88.16 High High
Hippocampus 26 87.00 High High
Central nervous system 15 68.60 Quite High
IPN 2 68.16 Quite High
Inflammation 6 60.32 Quite High
spinothalamic 2 56.40 Quite High
spinal dorsal horn 2 50.00 Quite Low
Pain 17 46.56 Quite Low
Lasting pain 11 13.36 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 68.16 Quite High
INFLAMMATION 6 60.32 Quite High
Nociception 27 59.28 Quite High
Cognitive Disorder 2 40.72 Quite Low
Pain 25 21.04 Low Low
Stress 10 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated CREB, which may be activated by various signaling pathways, can directly modulate the expression of NK-1 receptor and BDNF genes through the CRE sites on their promoter regions.
CREB Regulation (modulate) of Gene_expression (expression) of BDNF
1) Confidence 0.25 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.25 Pain Relevance 0.49

General Comments

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