INT2191

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Context Info
Confidence 0.04
First Reported 1979
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.23
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
spikes 1
Rmp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 15 99.54 Very High Very High Very High
Pyramidal cell 31 87.04 High High
antagonist 3 75.00 Quite High
dopamine receptor 1 75.00 Quite High
Action potential 38 74.16 Quite High
Anterior cingulate cortex 61 52.48 Quite High
anesthesia 2 25.00 Low Low
Neuropathic pain 19 5.00 Very Low Very Low Very Low
Lasting pain 5 5.00 Very Low Very Low Very Low
amygdala 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 94.48 High High
Neuropathic Pain 29 5.00 Very Low Very Low Very Low
Nervous System Injury 17 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the RMP, in response to different intensities of current pulses, cells fired trains of spikes with the first spike followed by the postspike fAHP, ADP, and sAHP (Fig. 4F).


Negative_regulation (fired) of RMP in spikes
1) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2807858 Disease Relevance 0 Pain Relevance 0.22
Intrarenal arterial (i.a.) infusions of prostacyclin (PGI2) at 30-300 ng/min to anaesthetized dogs reduced renal vascular resistance (RVR) and filtration fraction (FF), increased mean renal blood flow (MRBF) but did not alter mean arterial pressure (MAP)or glomerular filtration rate (GFR).
Negative_regulation (reduced) of resistance in blood
2) Confidence 0.00 Published 1979 Journal Prostaglandins Section Abstract Doc Link 375317 Disease Relevance 0.13 Pain Relevance 0
Intravenous (i.v.) administration of TA-870 in anesthetized dogs produced a dose-dependent increase in free DA in blood and caused a decrease in renal vascular resistance (RVR) and an increase in renal blood flow (RBF).
Negative_regulation (decrease) of resistance in blood associated with dopamine
3) Confidence 0.00 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1711621 Disease Relevance 0.09 Pain Relevance 0.58

General Comments

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