INT219108

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 9.74
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC5AC) cell adhesion (MUC5AC)
Anatomy Link Frequency
eye 2
epithelium 2
lung 2
goblet cell 2
MUC5AC (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 80 98.72 Very High Very High Very High
chemokine 46 92.28 High High
cytokine 183 91.68 High High
gABA 177 86.24 High High
imagery 7 84.64 Quite High
GABAergic 138 84.48 Quite High
Inflammation 220 81.68 Quite High
headache 2 81.48 Quite High
Neurotransmitter 12 80.80 Quite High
Central nervous system 10 78.08 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 52 100.00 Very High Very High Very High
Hyperplasia 35 100.00 Very High Very High Very High
Nicotine Addiction 337 99.72 Very High Very High Very High
Metaplasia 57 99.18 Very High Very High Very High
Eosinophilia 38 98.64 Very High Very High Very High
Eye Disease 10 98.64 Very High Very High Very High
Asthma 643 98.30 Very High Very High Very High
Infection 57 98.16 Very High Very High Very High
Malignant Neoplastic Disease 8 98.16 Very High Very High Very High
Pulmonary Disease 73 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of mucins in dry eye disease has mainly focused on MUC5AC, and it is generally assumed that the expression of MUC5AC is reduced in dry eyed subjects [29].
Negative_regulation (reduced) of Gene_expression (expression) of MUC5AC in eye associated with eye disease
1) Confidence 0.31 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.41 Pain Relevance 0
median + 1 standard deviation and low GAD67 or low MUC5AC gene expression as ?
Negative_regulation (low) of Gene_expression (expression) of MUC5AC gene
2) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.24 Pain Relevance 0.04
We down-regulated MUC5AC expression by siRNA and investigated the effects on the malignant and metastatic potential of human pancreatic cancer cell lines, SW1990 and BxPC3.


Negative_regulation (regulated) of Gene_expression (expression) of MUC5AC associated with malignant neoplastic disease and pancreatic cancer
3) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 0.94 Pain Relevance 0
Reduced expression of MUC5AC in SW1990 and BxPC3 cells
Negative_regulation (Reduced) of Gene_expression (expression) of MUC5AC
4) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 0.32 Pain Relevance 0
Suppression of MUC5AC reduced expression of integrins and production of MMP-3 and VEGF
Negative_regulation (reduced) of Gene_expression (expression) of MUC5AC associated with metalloproteinase
5) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 0.46 Pain Relevance 0.11
Suppression of MUC5AC reduced expression of integrins and production of MMP-3 and VEGF
Negative_regulation (Suppression) of Gene_expression (expression) of MUC5AC associated with metalloproteinase
6) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 0.46 Pain Relevance 0.11
Histological analysis of lungs from these animals demonstrated reduced goblet cell metaplasia and mucus staining that correlated with inhibition of MUC5AC gene expression in lung tissue.
Negative_regulation (inhibition) of Gene_expression (expression) of MUC5AC in lung associated with metaplasia
7) Confidence 0.28 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.89 Pain Relevance 0.22
There was a positive correlation between GAD67 gene expression and MUC5AC at the mRNA level in both small and large airway epithelium, as well as by MUC5AC staining, suggesting a link between mucus overproduction and GAD67 overexpression in association with smoking.
Negative_regulation (correlation) of Gene_expression (expression) of MUC5AC in epithelium associated with nicotine addiction
8) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.52 Pain Relevance 0.44
Based on the microarray data, we defined "high GAD67" or "high MUC5AC" gene expression as ?
Negative_regulation (defined) of Gene_expression (expression) of MUC5AC
9) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.22 Pain Relevance 0.04
In addition, small airway epithelial MUC5AC expression is lower in ex-smokers compared to current smokers with and without COPD [29], which is also in line with our conclusion.
Negative_regulation (lower) of Gene_expression (expression) of MUC5AC associated with pulmonary disease and nicotine addiction
10) Confidence 0.26 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.60 Pain Relevance 0
Interestingly, in an animal model of asthma niflumic acid, a relatively specific blocker of calcium-activated chloride channel, inhibits IL-13-induced goblet cell hyperplasia, MUC5AC expression, airway hyperresponsiveness, BAL eosinophilia and eotaxin increase.
Negative_regulation (inhibits) of Gene_expression (expression) of MUC5AC in goblet cell associated with asthma, eosinophilia and hyperplasia
11) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.77 Pain Relevance 0.03
At 1–4 weeks after inoculation, Leb (Figure 3B) and/or Lea expression (data not shown) transiently decreased in 5/7 monkeys.
Negative_regulation (decreased) of Gene_expression (expression) of Leb
12) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 1.02 Pain Relevance 0
Severity of TBM was staged according to Medical Research Council (MRC) criteria.[9]

Microbiological Evaluation

Negative_regulation (staged) of Gene_expression (Severity) of TBM associated with mycobacterial infection
13) Confidence 0.15 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2924511 Disease Relevance 0.90 Pain Relevance 0.08

General Comments

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