INT219152

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP3, CASP1) signal transduction (NLRP3, CASP1) cytoplasm (NLRP3, CASP1)
peptidase activity (CASP1) intracellular (CASP1)
NLRP3 (Homo sapiens)
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 97.08 Very High Very High Very High
antagonist 6 51.60 Quite High
anakinra 1 50.00 Quite Low
tolerance 3 44.44 Quite Low
vagus nerve 2 42.72 Quite Low
agonist 6 20.48 Low Low
cytokine 11 18.64 Low Low
chemokine 3 9.28 Low Low
psoriasis 7 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 97.08 Very High Very High Very High
Crystal Associated Disease 4 82.96 Quite High
Diabetes Mellitus 1 73.08 Quite High
Autoimmune Disease 8 61.08 Quite High
Hodgkin's Disease 1 59.00 Quite High
Disease 24 58.56 Quite High
Syndrome 1 56.80 Quite High
Shock 1 39.52 Quite Low
Injury 1 38.16 Quite Low
Mucocutaneous Lymph Node Syndrome 1 26.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cryopyrin/NALP3, the best-characterized NLR molecule, mediates caspase-1 activation upon binding of muropeptides, peptidoglycan fragments derived from the gram-positive and negative bacteria.
NALP3 Positive_regulation (mediates) of Positive_regulation (activation) of caspase-1
1) Confidence 0.02 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.83 Pain Relevance 0.10

General Comments

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