INT219154

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.45
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HMGB1, TLR4) nucleoplasm (HMGB1) intracellular (TLR4)
DNA binding (HMGB1) signal transduction (TLR4) extracellular space (HMGB1)
Anatomy Link Frequency
neurons 2
HMGB1 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal excitability 2 86.48 High High
cytokine 21 84.80 Quite High
Inflammation 46 81.20 Quite High
gABA 2 80.08 Quite High
Glutamate 2 79.72 Quite High
Neurotransmitter 2 79.00 Quite High
chemokine 3 64.68 Quite High
Multiple sclerosis 109 50.00 Quite Low
antiepileptic Drug 18 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 37 99.04 Very High Very High Very High
Epilepsy 132 98.08 Very High Very High Very High
Death 3 89.12 High High
Convulsion 110 88.16 High High
Multiple Myeloma 1 84.52 Quite High
Benign Monoclonal Gammopathies 1 82.16 Quite High
INFLAMMATION 39 81.20 Quite High
Breast Cancer 4 81.20 Quite High
Malignant Neoplastic Disease 1 80.20 Quite High
Lymphatic System Cancer 5 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of innate immunity was further supported by a recent study performed in spontaneously epileptic mice and in human TLE showing a new proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from neurons and glia and its interaction with Toll-like receptor 4 (TLR4) [23].
HMGB1 Binding (interaction) of Toll-like receptor 4 in neurons associated with epilepsy
1) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.42 Pain Relevance 0.44
The role of innate immunity was further supported by a recent study performed in spontaneously epileptic mice and in human TLE showing a new proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from neurons and glia and its interaction with Toll-like receptor 4 (TLR4) [23].
HMGB1 Binding (interaction) of TLR4 in neurons associated with epilepsy
2) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.42 Pain Relevance 0.44
HMGB-1 appears to associate with TLR4 and promote the uptake of tumor cells rather than the activation of DC.
HMGB-1 Binding (associate) of TLR4 associated with cancer
3) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.62 Pain Relevance 0.06

General Comments

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