INT219159

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.37
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR7) signal transduction (TLR7) endoplasmic reticulum (TLR7)
plasma membrane (TLR7) intracellular (TLR7) lysosome (TLR7)
Anatomy Link Frequency
monocytes 1
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 138 100.00 Very High Very High Very High
cytokine 30 98.84 Very High Very High Very High
Inflammation 134 98.12 Very High Very High Very High
antagonist 72 93.84 High High
psoriasis 7 89.36 High High
rheumatoid arthritis 6 63.84 Quite High
Inflammatory response 26 59.52 Quite High
chemokine 3 55.76 Quite High
tolerance 5 51.12 Quite High
Arthritis 11 45.40 Quite Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 63 98.76 Very High Very High Very High
INFLAMMATION 164 98.12 Very High Very High Very High
Autoimmune Disease 10 93.32 High High
Neutropenia 1 90.32 High High
Psoriasis 8 89.36 High High
Paroxysmal Nocturnal Hemoglobinuria 1 84.52 Quite High
Graft Vs Host Disease 5 70.04 Quite High
Influenza Virus Infection 1 68.80 Quite High
Herpes Simplex Virus 2 67.76 Quite High
Rheumatoid Arthritis 6 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are consistent with observations showing that TLR8 engagement is more effective than TLR7 activation in inducing proinflammatory cytokine production from human monocytes (37).
Positive_regulation (activation) of TLR7 in monocytes associated with cytokine
1) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.06 Pain Relevance 0.08
g/ml because these concentrations are reported to activate TLR7 only and TLR7/8, respectively.
Positive_regulation (activate) of TLR7
2) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.25
Gardiquimod, when applied at supramaximal concentrations required to activate TLR7, was ineffective at mediating any early (3 h) ATP-independent IL-1?
Positive_regulation (activate) of TLR7
3) Confidence 0.37 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.09 Pain Relevance 0.12
g/ml to selectively activate TLR7, had no effect on this release.
Neg (no) Positive_regulation (activate) of TLR7
4) Confidence 0.37 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.10
CL097 (InvivoGen), a water-soluble derivative of the imidazoquinoline compound R848 shown to induce activation of TLR7 at 0.1 ?
Positive_regulation (activation) of TLR7
5) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.11
Our work is supported by the recent findings by Hurst et al. (42), who describe TLR7/8 agonist induction of IL-1?
Positive_regulation (induction) of TLR7 associated with agonist
6) Confidence 0.32 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.13 Pain Relevance 0.16
SLE is associated with an increased production of Type I IFNs, most likely derived from pDCs following activation via TLR7 or TLR9.
Positive_regulation (activation) of TLR7 associated with systemic lupus erythematosus
7) Confidence 0.28 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.28 Pain Relevance 0.39
TLR-7 and -9 activation induces secretion of interferons and promotes inflammation.
Positive_regulation (activation) of TLR-7 associated with inflammation
8) Confidence 0.05 Published 2010 Journal BMC Med Section Body Doc Link PMC3009611 Disease Relevance 0.73 Pain Relevance 0.11

General Comments

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