INT219161

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL9) extracellular space (CXCL9) extracellular region (CXCL9)
cell-cell signaling (CXCL9)
Anatomy Link Frequency
lymph nodes 1
T cell 1
CXCL9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 99.84 Very High Very High Very High
Inflammatory response 3 92.96 High High
chemokine 18 80.88 Quite High
cytokine 19 57.32 Quite High
agonist 8 44.32 Quite Low
psoriasis 7 33.64 Quite Low
Bioavailability 1 31.04 Quite Low
Multiple sclerosis 1 30.92 Quite Low
antagonist 6 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.84 Very High Very High Very High
Mycobacterial Infection 4 94.12 High High
General Immunology 4 92.04 High High
Immunization 15 84.24 Quite High
Infection 17 76.48 Quite High
Papillomavirus Infection 18 50.00 Quite Low
Psoriasis 8 33.64 Quite Low
Demyelinating Disease 1 30.92 Quite Low
Disease 24 29.76 Quite Low
Viral Infection 1 23.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCR3+CD8+ T cells migrate to reactive, but not resting, lymph nodes (LN) in response to CXCL9, which is transiently secreted by inflammatory high endothelial venules (HEV).
Localization (secreted) of CXCL9 in lymph nodes associated with inflammation
1) Confidence 0.44 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.34 Pain Relevance 0.15
Studies in mice revealed additionally that CXCL10 is secreted early (e.g., earlier than CXCL9, which we did not detect at the same levels in the serum as CXCL10) [73], and stimulates T cell proliferation [74].
Localization (secreted) of CXCL9 in T cell
2) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

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