INT219175

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR7) signal transduction (TLR7) endoplasmic reticulum (TLR7)
plasma membrane (TLR7) intracellular (TLR7) lysosome (TLR7)
Anatomy Link Frequency
Monocytes 1
T cell 1
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 28 100.00 Very High Very High Very High
cytokine 14 99.60 Very High Very High Very High
Inflammation 35 54.40 Quite High
psoriasis 7 51.04 Quite High
antagonist 17 45.68 Quite Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 92.56 High High
Infection 9 84.40 Quite High
Disease 31 58.24 Quite High
Communicable Diseases 5 56.24 Quite High
INFLAMMATION 41 54.40 Quite High
Cancer 37 52.96 Quite High
Autoimmune Disease 8 52.64 Quite High
Psoriasis 8 51.04 Quite High
Immunotherapy Of Cancer 2 37.72 Quite Low
Skin Cancer 6 30.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocytes stimulated for 24 h with the TLR7 agonist gardiquimod released IL-1?
Localization (released) of TLR7 in Monocytes associated with agonist
1) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.05
Vaccines with TLR7/8 ligand and gag without conjugation induced poor antigen-specific T cell immunity, and the secretion of fewer cytokines.
Localization (secretion) of TLR7 in T cell associated with cytokine
2) Confidence 0.37 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.32 Pain Relevance 0.20

General Comments

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