INT219193

Context Info Confidence 0.24 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.26

cytoplasm (Nlrp3, NLRP3) cytosol (NLRP3) signal transduction (NLRP3)

Nlrp3 (Mus musculus) NLRP3 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 16 94.00 antagonist 6 86.00 anakinra 1 84.40 vagus nerve 2 77.12 agonist 6 54.88 cytokine 11 53.04 Arthritis 2 32.56 tolerance 3 25.88 psoriasis 7 5.00 chemokine 3 5.00

Disease Link Frequency Relevance Heat Crystal Associated Disease 4 98.44 INFLAMMATION 17 94.00 Disease 24 92.96 Syndrome 1 91.20 Shock 1 73.92 Injury 1 72.56 Diabetes Mellitus 1 54.52 Autoimmune Disease 8 42.52 Hodgkin's Disease 1 40.44 Septic Shock 1 33.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A constitutively active form of mutated NALP3/cryopyrin, which promotes IL-1?

cryopyrin Positive_regulation (promotes) of Positive_regulation (mutated) of NALP3

1) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.03 Pain Relevance 0.26

General Comments

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