INT219219

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.29
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Rgc32) cytoskeleton (Rgc32) nucleus (Rgc32)
cell cycle (Rgc32) microtubule organizing center (Rgc32) cytoplasm (Rgc32)
Anatomy Link Frequency
neurons 1
optic nerve 1
Rgc32 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 36 95.76 Very High Very High Very High
imagery 68 90.56 High High
ischemia 36 90.24 High High
anesthesia 8 83.60 Quite High
ketamine 4 61.12 Quite High
lidocaine 3 59.20 Quite High
Glutamate 170 34.40 Quite Low
excitatory amino acid 5 11.76 Low Low
Inflammation 12 10.40 Low Low
cytokine 3 9.36 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 245 100.00 Very High Very High Very High
Death 89 100.00 Very High Very High Very High
Nonarteritic Anterior Ischaemic Optic Neuropathy 36 99.98 Very High Very High Very High
Glaucoma 280 99.56 Very High Very High Very High
Gliosis 3 99.48 Very High Very High Very High
Injury 13 98.16 Very High Very High Very High
Ocular Hypertension 78 97.80 Very High Very High Very High
Stroke 66 96.60 Very High Very High Very High
Cv Unclassified Under Development 30 90.24 High High
Ganglion Cysts 32 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present studies on albino and pigmented rats, as well as those of others on pigmented rats [7], underline the potential use of the STR components of the ERG as a functional index to demonstrate in vivo RGC dysfunction in several experimental models involving RGC injury, such as an acute [64,65] or chronic increase in intraocular pressure [66–68].
Gene_expression (dysfunction) of RGC associated with injury and ocular hypertension
1) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.55 Pain Relevance 0
There was an average 65% loss of RGCs in estrogen-treated animals and 70% RGC loss in vehicle treated animals.
Gene_expression (loss) of RGC
2) Confidence 0.08 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185481 Disease Relevance 0.43 Pain Relevance 0.04
Induction levels were adjusted to produce a predicted loss of 60%–75% RGC loss (data not shown).
Gene_expression (produce) of RGC
3) Confidence 0.08 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185481 Disease Relevance 0.17 Pain Relevance 0.09
Detection of RGC apoptosis in glaucoma-related animal models with DARC
Gene_expression (Detection) of RGC associated with glaucoma and apoptosis
4) Confidence 0.08 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.76 Pain Relevance 0.23
is a likely mediator of pressure-induced RGC death and that targeting multiple stages in the A?
Gene_expression (death) of RGC associated with death
5) Confidence 0.08 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.00 Pain Relevance 0
deposition in experimental glaucoma and its induction of RGC apoptosis in vivo suggests that A?
Gene_expression (apoptosis) of RGC associated with glaucoma and apoptosis
6) Confidence 0.08 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.15 Pain Relevance 0.04
NAION produces RGC loss and ON gliosis, with sparing of other retinal neurons [3,5].
Gene_expression (produces) of RGC in neurons associated with nonarteritic anterior ischaemic optic neuropathy and gliosis
7) Confidence 0.07 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185481 Disease Relevance 1.16 Pain Relevance 0.24
formation and aggregation might reduce RGC apoptosis, we examined three different agents, including a ?
Gene_expression (apoptosis) of RGC associated with apoptosis
8) Confidence 0.07 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.12 Pain Relevance 0.04
In an optic nerve transaction rat model, we recorded RGC apoptosis in 0.3, 1, 8, and 4% of total RGCs, with RGC losses of 0, 3, 49, and 76% at 0, 3, 7, and 12 days, respectively.
Gene_expression (apoptosis) of RGC in optic nerve associated with apoptosis
9) Confidence 0.07 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.94 Pain Relevance 0.16

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