INT219224

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 21
Disease Relevance 12.91
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 4
liver 3
eye 3
plasma 2
anterior 2
Ighv10-3 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 21 82.60 Quite High
anesthesia 21 42.52 Quite Low
Inflammation 21 12.52 Low Low
cytokine 21 10.96 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1176 99.88 Very High Very High Very High
Cataract 210 98.80 Very High Very High Very High
Injury 21 97.32 Very High Very High Very High
Eye Disease 63 94.52 High High
Adenocarcinoma 21 94.32 High High
Adhesions 126 92.76 High High
Corneal Disease 42 91.88 High High
Congenital Anomalies 210 90.08 High High
Corneal Opacity 273 90.00 High High
Fetal Alcohol Syndrome 21 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the age of two months, when plasma could safely be collected, the level of hßigh3 was measured in all wild-type and transgenic mice to establish hßigh3 overexpression in plasma.
Gene_expression (overexpression) of igh3 in plasma associated with targeted disruption
1) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.89 Pain Relevance 0
igh3 is involved in anterior segment morphogenesis and must be properly expressed for normal anterior segment development.
Gene_expression (expressed) of igh3 in anterior
2) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.90 Pain Relevance 0.04
A high level of hßigh3 expression was also observed by western blot analysis in the plasma of transgenic mice (Figure 1E).
Gene_expression (expression) of igh3 in plasma associated with targeted disruption
3) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.65 Pain Relevance 0
igh3 was produced under control of the albumin promoter (Figure 1D).
Gene_expression (produced) of igh3
4) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 1.06 Pain Relevance 0
igh3 is a secretory protein and hßigh3 ectopically expressed in liver under the control of Alb promoter was able to secrete into blood.
Gene_expression (expressed) of igh3 in blood
5) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.26 Pain Relevance 0
igh3 is ubiquitously expressed in many normal human tissues such as the heart, liver, pancreas, and skin, suggesting that it may have an important function throughout the body [1].
Gene_expression (expressed) of igh3 in skin
6) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.26 Pain Relevance 0
Figure 1B-D show representative data for hßigh3 transgene expression in 28 transgenic mice.
Gene_expression (expression) of igh3 associated with targeted disruption
7) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.63 Pain Relevance 0
igh3 expression must be properly maintained during ocular development.
Gene_expression (expression) of igh3
8) Confidence 0.03 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2185514 Disease Relevance 0.97 Pain Relevance 0
Gross phenotype and electron microscopic examination of the mice eyes with hßigh3 overexpression
Gene_expression (overexpression) of igh3 in eyes
9) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.93 Pain Relevance 0
igh3 expression must be critically maintained during ocular development to avoid severe deformity, especially in the cornea.
Gene_expression (expression) of igh3 in cornea
10) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.77 Pain Relevance 0.03
Additionally, even though hßigh3 was overexpressed in the entire mouse body through the blood stream, the effect was observed only in the eye.
Gene_expression (overexpressed) of igh3 in blood
11) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 1.16 Pain Relevance 0
igh3 is not only expressed in the cornea of the normal human eye but also in healing corneal wounds [4-6].
Gene_expression (expressed) of igh3 in eye associated with injury
12) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.31 Pain Relevance 0
Transgenic mice also showed strong expression of the hßigh3 transgene in liver hepatocytes and in corneal epithelium by immunostaining (Figure 1D).
Gene_expression (expression) of igh3 in liver associated with targeted disruption
13) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.56 Pain Relevance 0
igh3 overexpression in mouse eye.
Gene_expression (overexpression) of igh3 in eye
14) Confidence 0.03 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2185514 Disease Relevance 0.74 Pain Relevance 0
igh3 expression greatly increased in lens epithelial cells from patients with anterior polar cataracts and in human lens epithelial cells treated with TGF-?
Gene_expression (expression) of igh3 in anterior associated with cataract
15) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 1.10 Pain Relevance 0
igh3 is a secretory protein and hßigh3 ectopically expressed in liver under the control of Alb promoter was able to secrete into blood.
Gene_expression (expressed) of igh3 in blood
16) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.20 Pain Relevance 0
Transgenic mice overexpressing normal hßigh3 in the liver and blood
Gene_expression (overexpressing) of igh3 in blood associated with targeted disruption
17) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.38 Pain Relevance 0
igh3 is ubiquitously expressed in many normal human tissues such as the heart, liver, pancreas, and skin, suggesting that it may have an important function throughout the body [1].
Gene_expression (expressed) of igh3 in liver
18) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.26 Pain Relevance 0
igh3 is ubiquitously expressed in many normal human tissues such as the heart, liver, pancreas, and skin, suggesting that it may have an important function throughout the body [1].
Gene_expression (expressed) of igh3 in pancreas
19) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.26 Pain Relevance 0
igh3 is ubiquitously expressed in many normal human tissues such as the heart, liver, pancreas, and skin, suggesting that it may have an important function throughout the body [1].
Gene_expression (expressed) of igh3 in heart
20) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.26 Pain Relevance 0

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