INT21925

Context Info Confidence 0.37 First Reported 1990 Last Reported 2006 Negated 1 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.64 Pain Relevance 0.70

small molecule metabolic process (PLB1) plasma membrane (PLB1)

Anatomy Link Frequency endothelial cells 1 lip 1 heart 1 PLB1 (Homo sapiens)

Pain Link Frequency Relevance Heat interstitial cystitis 2 98.92 lidocaine 6 98.68 Inflammation 2 97.24 Inflammatory mediators 2 92.36 palliative 33 50.00 Morphine 38 5.00 Opioid 37 5.00 tolerance 11 5.00 depression 9 5.00 sSRI 8 5.00

Disease Link Frequency Relevance Heat Interstitial Cystitis 2 98.92 Dyspnea 137 98.64 INFLAMMATION 4 97.24 Pulmonary Disease 84 95.60 Anxiety Disorder 22 45.28 Shock 1 37.12 Panic Disorder 2 32.96 Cancer 3 26.24 Disease Progression 1 14.44 Lung Cancer 19 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We examined the effect of multiple phospholipase A2 and cyclooxygenase inhibitors on the immediate release of prostacyclin from human bladder microvascular endothelial cells.

Spec (examined) Regulation (effect) of phospholipase A2 in endothelial cells

1) Confidence 0.37 Published 2006 Journal J. Urol. Section Abstract Doc Link 16952710 Disease Relevance 0.29 Pain Relevance 0.19

CONCLUSIONS: These results show that the search for a suitable anti-inflammatory agent that selectively target specific phospholipase A2 isoforms requires rigorous testing in several cell types in response to various stimuli.

Regulation (target) of phospholipase A2

2) Confidence 0.22 Published 2006 Journal J. Urol. Section Body Doc Link 16952710 Disease Relevance 0 Pain Relevance 0

Several controlled breathing techniques including positioning and pursed lip breathing (PLB) are useful in the management of breathlessness.

Regulation (controlled) of PLB in lip associated with dyspnea

3) Confidence 0.12 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707160 Disease Relevance 0.35 Pain Relevance 0

When the heart was perfused with 0.5 mg methyl lidocaine/mL, acyltransferase activities were attenuated, but there was no change in the activities of phospholipase A or lysophospholipase.

Neg (no) Regulation (change) of lysophospholipase in heart associated with lidocaine

4) Confidence 0.03 Published 1990 Journal Biochem. Cell Biol. Section Abstract Doc Link 2222999 Disease Relevance 0 Pain Relevance 0.51

General Comments

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