INT219256

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddx41, G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
helicase activity (Ddx41) ligase activity (G2e3) cytoplasm (G2e3)
Anatomy Link Frequency
HeLa 1
Ddx41 (Mus musculus)
G2e3 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 135 97.38 Very High Very High Very High
Infection 150 95.96 Very High Very High Very High
Vibrio Infection 20 87.96 High High
Influenza Virus Infection 25 75.00 Quite High
Sprains And Strains 30 70.84 Quite High
Bacterial Infection 5 53.08 Quite High
Lower Respiratory Tract Infection 15 5.00 Very Low Very Low Very Low
Weight Loss 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Exsanguination 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Independent of adjuvants and immunization route, on average 87% of the M2e-MAP-induced Abs were specific for M2e peptide and a variable fraction of these M2e(pep)-specific Abs (average 15%) cross-reacted with presumably native M2e expressed by M2-transfected cells.
Abs Binding (reacted) of M2e associated with immunization
1) Confidence 0.01 Published 2007 Journal Virol J Section Abstract Doc Link PMC2186315 Disease Relevance 0.49 Pain Relevance 0
Since the latter Abs are a fraction of the M2e(pep)-specific Abs, they will be referred to as M2e(pep-nat)-specific to distinguish them from Abs that react with native cell-expressed M2e but not with M2e peptide, an Ab population detected in mice that have recovered from repetitive IAV infections [13].
Abs Binding (react) of M2e associated with infection
2) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.23 Pain Relevance 0
We were interested in learning what fraction of the total M2e-MAP-induced Ab response was specific for M2e peptide and what fraction of the M2e-peptide-specific Abs was capable of binding to native tetrameric M2e.
Abs Binding (binding) of M2e
3) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.21 Pain Relevance 0
A variable fraction (on average 15%) of these M2e(pep)-specific Abs cross-reacted with presumably native tetrameric M2e expressed by M2-transfected HeLa cells, and the concentration of these M2e(pep-nat)-specific Abs in sera of parenterally immunized mice showed a good correlation with protection against virus challenge.
Abs Binding (reacted) of M2e in HeLa
4) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.48 Pain Relevance 0
The latter was of particular interest because only Abs capable of binding to native tetrameric M2e would be expected to display protective activity.
Abs Binding (binding) of M2e
5) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.21 Pain Relevance 0

General Comments

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