INT219279

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctss) nucleolus (Fam64a) molecular_function (Fam64a)
biological_process (Fam64a) lysosome (Ctss)
Anatomy Link Frequency
cleavage 1
microglia 1
Ctss (Mus musculus)
Fam64a (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 61 99.96 Very High Very High Very High
dorsal root ganglion 9 97.76 Very High Very High Very High
Hyperalgesia 4 93.44 High High
metalloproteinase 1 87.52 High High
Dorsal horn neuron 1 86.80 High High
intrathecal 5 76.96 Quite High
chemokine 5 74.16 Quite High
allodynia 7 72.48 Quite High
Spinal cord 17 66.72 Quite High
substance P 2 55.96 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 32 100.00 Very High Very High Very High
Neuropathic Pain 69 99.96 Very High Very High Very High
Ganglion Cysts 9 97.76 Very High Very High Very High
Hyperalgesia 4 93.44 High High
Adhesions 1 91.48 High High
Targeted Disruption 1 37.32 Quite Low
Pain 24 27.56 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Spinal Cord Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study shows that cysteine protease cathepsin S (CatS), which is produced in microglia after nerve injury, can enhance neuropathic pain by cleavage of FKN on the membrane of DRG neurons.
cathepsin S Positive_regulation (enhance) of in cleavage Gene_expression (produced) of CatS in microglia associated with dorsal root ganglion, nervous system injury and neuropathic pain
1) Confidence 0.06 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.39 Pain Relevance 0.96

General Comments

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