INT219292

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.87
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Fabp4) cytosol (Fabp4) transport (Fabp4)
nucleus (Fabp4) cytoplasm (Fabp4)
Anatomy Link Frequency
bar 2
adipose tissue 2
adipocyte 2
myometrium 1
hepatocytes 1
Fabp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 221 92.12 High High
agonist 152 90.52 High High
tolerance 108 83.12 Quite High
Neuritis 10 50.08 Quite High
potassium channel 4 50.00 Quite Low
Multiple sclerosis 9 41.76 Quite Low
Spinal cord 1 12.80 Low Low
COX2 45 5.00 Very Low Very Low Very Low
antagonist 29 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 234 100.00 Very High Very High Very High
Targeted Disruption 118 99.04 Very High Very High Very High
Age-related Macular Degeneration 36 93.16 High High
Atherosclerosis 1 93.04 High High
Ocular & Orbital Inflammation 3 92.12 High High
Impaired Glucose Tolerance 112 83.12 Quite High
Disease 64 81.84 Quite High
Rheumatoid Arthritis 8 70.72 Quite High
Stress 7 70.08 Quite High
Ocular Toxicity (including Many Sub-types) 6 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In another line of transgenic mice, Zhang et al. created animals in which the ghrelin gene is overexpressed in adipose tissue via the fatty acid-binding protein-4 (FABP4) promoter.
Gene_expression (overexpressed) of FABP4 in adipose tissue associated with targeted disruption and obesity
1) Confidence 0.46 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.90 Pain Relevance 0.12
In another line of transgenic mice, Zhang et al. created animals in which the ghrelin gene is overexpressed in adipose tissue via the fatty acid-binding protein-4 (FABP4) promoter.
Gene_expression (overexpressed) of fatty acid-binding protein-4 in adipose tissue associated with targeted disruption and obesity
2) Confidence 0.46 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.90 Pain Relevance 0.12
L-FABP is highly expressed in the liver and small intestine, where it
Gene_expression (expressed) of FABP in small intestine
3) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.14 Pain Relevance 0
- in these cells led to a significant reduction of aP2 expression (bar 2 vs. 4 and 6, Figure 2B) indicating that endogenous PPAR?
Gene_expression (expression) of aP2 in bar
4) Confidence 0.32 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
(Figure 2C). aP2 expression level was also significantly reduced in cells co-expressing ER?
Gene_expression (expression) of aP2
5) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
The adipocyte protein 2 (aP2) gene belongs to the classical PPAR?
Gene_expression (The) of aP2 in adipocyte
6) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
The expression level of aP2 measured by real-time PCR was significantly elevated in the differentiated control cells (bar 2 vs. 1, Figure 2B).
Gene_expression (expression) of aP2 in bar
7) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
Fabp4 expression in hepatocytes is correlated with acquisition of a steatotic phenotype concurrent with upregulation of PPAR?
Gene_expression (expression) of Fabp4 in hepatocytes
8) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.07
induce expression of adipocyte lipid binding protein (ALBP/aP2), a gene that is
Gene_expression (expression) of adipocyte lipid binding protein in adipocyte
9) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0.78 Pain Relevance 0.21
L-FABP is highly expressed in the liver and small intestine, where it
Gene_expression (expressed) of FABP in liver
10) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.14 Pain Relevance 0
M 4-AP (the concentration at which contractile responses become maximal in nonpregnant myometrium), mean contractile responses to 4-AP in samples taken from mice from each stage of gestation (P7, P10, P15, and P20) were significantly reduced compared to those found in nonpregnant samples (Figure 7.a).
Gene_expression (reduced) of P15 in myometrium
11) Confidence 0.10 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0

General Comments

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