INT219295

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.21
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnc1) transmembrane transport (Kcnc1)
Anatomy Link Frequency
myometrium 4
uterus 1
band 1
Kcnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 6 88.72 High High
Thalamus 1 78.36 Quite High
Hippocampus 5 75.52 Quite High
Pyramidal cell 8 70.40 Quite High
Action potential 18 58.48 Quite High
potassium channel 24 56.52 Quite High
Calcium channel 6 23.48 Low Low
agonist 30 5.00 Very Low Very Low Very Low
tetrodotoxin 12 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 88.72 High High
Sprains And Strains 7 66.08 Quite High
Dislocations 6 52.80 Quite High
Targeted Disruption 4 7.48 Low Low
Disease 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 1 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
subunits shown in Figure 5 (e.g. there appears to be a little more Kv1.1 expression in term-pregnant myometrium than in nonpregnant tissues), we are unwilling at present to ascribe any significance to these differences other than the profound reduction in Kv4.3 expression which occurs near the end of gestation (Figures 5 and 7), a finding which is consistent with those of Song et al. [19] who found a reduction in Kv4.3 mRNA and protein expression in pregnant rat uterus which appears to be dependent upon estrogen.
Negative_regulation (reduction) of Kv4 in uterus
1) Confidence 0.36 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0.03
Remarkably, contractile responses to 4-AP disappear in pregnant mouse myometrium, and this finding is correlated with the loss in expression of the Kv4.3 ?
Negative_regulation (loss) of Kv4 in myometrium
2) Confidence 0.36 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0.06
subunit proteins in myometrium from both pregnant and nonpregnant mice; we also provide evidence of a profound reduction in Kv4.3 ?
Negative_regulation (reduction) of Kv4 in myometrium
3) Confidence 0.32 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0.09 Pain Relevance 0.09
Furthermore, the disappearance of Kv4.3 expression and of responses to 4-AP and phrixotoxin-2 in pregnant myometrium may indicate a specific loss of Kv channel function at the point when the myometrium is being prepared for labour.


Negative_regulation (loss) of Kv in myometrium
4) Confidence 0.32 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0.12 Pain Relevance 0
We do not know with certainty that 4-AP causes contractions in nonpregnant mouse myometrium by blocking Kv channels, nor can we claim that the disappearance of Kv4.3 channels at the end of pregnancy is clearly responsible for the loss of 4-AP responsiveness seen in these tissues.
Negative_regulation (blocking) of Kv in myometrium
5) Confidence 0.32 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0
Comparison by densitometry revealed a significant (p = 0.01) reduction in Kv4.3 band densities in term-pregnant (P20) vs. either nonpregnant or P7 through P15 animals (Figure 7.b).
Negative_regulation (reduction) of Kv4 in band
6) Confidence 0.32 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0
In addition, as discussed later, some structures apparently lacking Kv4.2 expressed DPP6 protein.
Negative_regulation (lacking) of Kv4
7) Confidence 0.29 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.17

General Comments

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