INT21934

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.91
Pain Relevance 11.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
LRF 4
output neurons 2
spinal cord 2
caudate-putamen 2
dorsal horn 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 66 100.00 Very High Very High Very High
Periaqueductal grey 63 100.00 Very High Very High Very High
GABAergic 28 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Rostral ventromedial medulla 3 99.80 Very High Very High Very High
spinothalamic tract 21 99.76 Very High Very High Very High
narcan 9 99.62 Very High Very High Very High
Cannabinoid 6 99.36 Very High Very High Very High
agonist 20 99.04 Very High Very High Very High
Opioid 10 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 129 100.00 Very High Very High Very High
Diabetes Mellitus 10 98.88 Very High Very High Very High
Hyperalgesia 4 90.32 High High
Injury 3 88.40 High High
Nociception 8 82.32 Quite High
Pain 12 52.08 Quite High
Peripheral Arterial Disease 1 25.00 Low Low
Headache 10 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Photophobia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the PAG-spinal cord pathway by analgesics such as opioids and cannabinoids is thought to be mediated by a reduction in the GABAergic inhibition of PAG and rostral ventromedial medulla output neurons, a process known as disinhibition.
Negative_regulation (reduction) of Negative_regulation (inhibition) of PAG in output neurons associated with gabaergic, cannabinoid, analgesic, periaqueductal grey, opioid, rostral ventromedial medulla and spinal cord
1) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.59 Pain Relevance 1.62
The mechanism whereby systemic methysergide reduces PAG spinal inhibition is unknown and cannot necessarily be related to a blockade of spinally released 5-hydroxytryptamine.
Negative_regulation (reduces) of Negative_regulation (inhibition) of PAG in spinal associated with periaqueductal grey
2) Confidence 0.30 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 4076338 Disease Relevance 0.41 Pain Relevance 0.45
Systemic methysergide (2-6 mg/kg i.v.) selectively reduced PAG-evoked inhibition in 6 units, while inhibitions from both PAG and LRF stimulation were reduced in one unit and unaffected in 8 units.
Negative_regulation (reduced) of Negative_regulation (inhibitions) of PAG in LRF associated with central grey
3) Confidence 0.27 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224516 Disease Relevance 0.78 Pain Relevance 0.97
Systemically administered naloxone (1-10 mg/kg i.v.) reduced (greater than 20% below predrug inhibition) inhibition from PAG and/or LRF in 5/12 units and had no effect in the remainder.
Negative_regulation (reduced) of Negative_regulation (inhibition) of PAG in LRF associated with narcan and central grey
4) Confidence 0.27 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224516 Disease Relevance 0.74 Pain Relevance 0.92
Another 5-HT3 antagonist, zacopride, did not increase the background activity or responses to PRESS and PINCH, yet this agent, like ondansetron, blocked PAG inhibition.
Negative_regulation (blocked) of Negative_regulation (inhibition) of PAG associated with antagonist and central grey
5) Confidence 0.22 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558419 Disease Relevance 0.66 Pain Relevance 0.77
Degree of PAG/NRD stimulation-produced inhibition of the VIR was dependent upon the strength of the test stimulus applied to the splanchnic nerve; the weaker the test stimulus, the more marked the inhibition.
Negative_regulation (Degree) of Negative_regulation (inhibition) of PAG in nerve associated with central grey
6) Confidence 0.19 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697757 Disease Relevance 0.96 Pain Relevance 0.56
In contrast, WDR STT cells in the superficial dorsal horn and high-threshold (HT) STT cells in superficial or deep layers showed reduced responses to mechanical stimulation of the skin after infusion of 8-bromo-cGMP, and PAG inhibition of these neurons was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Negative_regulation (inhibition) of PAG in neurons associated with spinothalamic tract, dorsal horn, central grey and wide dynamic range
7) Confidence 0.06 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9096162 Disease Relevance 0.45 Pain Relevance 1.33
However, perfusion of the spinal cord with NPC15437 (a selective PKC inhibitor) by microdialysis could prevent the sensitization of the responses to mechanical stimuli and the reduction in PAG inhibition of these responses induced by capsaicin injection.
Negative_regulation (reduction) of Negative_regulation (inhibition) of PAG in spinal cord associated with kinase c, qutenza, central grey and spinal cord
8) Confidence 0.04 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8622132 Disease Relevance 0.53 Pain Relevance 1.37
It is concluded that down-regulation of TRPV1 receptors in PAG is responsible for reduced antinociceptive effect of TRPV1 agonist.
Negative_regulation (down) of Negative_regulation (regulation) of PAG associated with agonist, antinociceptive and central grey
9) Confidence 0.02 Published 2010 Journal Brain Res. Section Abstract Doc Link 20211611 Disease Relevance 1.85 Pain Relevance 1.42
At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met- and leu-enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu-enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate-putamen.
Negative_regulation (reduction) of Negative_regulation (reduction) of PAG in caudate-putamen associated with periaqueductal grey and enkephalin
10) Confidence 0.02 Published 1986 Journal Mov. Disord. Section Abstract Doc Link 3504246 Disease Relevance 0.37 Pain Relevance 0.79
A reduction in PAG inhibition when STT cells were sensitized after intradermal injection of capsaicin could be nearly completely blocked by pretreatment of the dorsal horn with a NO synthase inhibitor, 7-nitroindazole.
Negative_regulation (reduction) of Negative_regulation (inhibition) of PAG in dorsal horn associated with spinothalamic tract, qutenza, dorsal horn and central grey
11) Confidence 0.01 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10085335 Disease Relevance 0.58 Pain Relevance 1.16

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