INT219349

Context Info Confidence 0.09 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 0

extracellular region (FGFR1, MMP11) cytosol (FGFR1) peptidase activity (MMP11) proteinaceous extracellular matrix (MMP11) cytoplasmic membrane-bounded vesicle (FGFR1) plasma membrane (FGFR1)

Anatomy Link Frequency brain 2 FGFR1 (Homo sapiens) MMP11 (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 3 8.56 metalloproteinase 4 5.00 Inflammation 2 5.00 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Stroke 53 100.00 Middle Cerebral Artery Infarction 25 100.00 Cv Unclassified Under Development 9 8.56 Death 8 5.00 Apoptosis 5 5.00 Cv General 4 Under Development 3 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Brain Injury 3 5.00 Injury 2 5.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using Western blotting and immunohistochemistry, PAK1, INI1 and MMP11 protein expression and localization was determined in the contralateral and ipsilateral brain areas of individual stroke patients and rats subjected to MCAO, and in HBMEC and HFN exposed to OGD and reperfusion.

OGD Positive_regulation (exposed) of Gene_expression (expression) of MMP11 in brain associated with middle cerebral artery infarction and stroke

1) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.55 Pain Relevance 0

General Comments

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