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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5)
cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)
Anatomy Link Frequency
neurons 1
CDK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 1 64.40 Quite High
Inflammation 32 58.48 Quite High
metalloproteinase 4 27.36 Quite Low
tetrodotoxin 1 21.20 Low Low
Ziconotide 1 10.12 Low Low
agonist 10 5.00 Very Low Very Low Very Low
complementary and alternative medicine 10 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 2 99.76 Very High Very High Very High
Injury 3 99.72 Very High Very High Very High
Death 18 99.28 Very High Very High Very High
Disease 19 97.80 Very High Very High Very High
Stroke 53 95.88 Very High Very High Very High
Adhesions 5 94.72 High High
Cancer 21 90.48 High High
Neuroblastoma 3 85.64 High High
Middle Cerebral Artery Infarction 25 75.52 Quite High
Prostate Cancer 1 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deregulation of CDK5/p25 has been associated with neurodegenerative diseases including Alzheimer’s disease, therefore it was included in the panel of kinases tested.
CDK5 Binding (associated) of associated with disease and neurodegenerative disease
1) Confidence 0.35 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 1.11 Pain Relevance 0.03
We have recently provided evidence for a potential role of Cdk5/p35 in the response to ischaemic injury as we showed association of Cdk5 with nuclear damage, by demonstrating co-expression of Cdk5 in TUNEL-positive neurons following human stroke and in propidium iodide-positive human foetal neurons following OGD [37].
Cdk5 Binding (association) of in neurons associated with stroke and injury
2) Confidence 0.16 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.58 Pain Relevance 0
Following extraction of total phosphorylated proteins, cellular moieties associated with cdk5-mediated exocytosis were identified.
cdk5 Binding (associated) of
3) Confidence 0.12 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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