INT219358

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 5.65
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5)
cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)
Anatomy Link Frequency
eosinophil 4
neurons 2
blood 1
dendrite 1
lateral 1
CDK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 102 92.84 High High
Central nervous system 34 89.40 High High
Neuritis 3 88.40 High High
Inflammation 220 84.96 Quite High
metalloproteinase 8 32.16 Quite Low
complementary and alternative medicine 50 5.00 Very Low Very Low Very Low
cytokine 41 5.00 Very Low Very Low Very Low
corticosteroid 25 5.00 Very Low Very Low Very Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
Kinase C 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 6 99.92 Very High Very High Very High
Injury 9 98.50 Very High Very High Very High
Stroke 106 98.28 Very High Very High Very High
Convulsion 3 96.48 Very High Very High Very High
Neurodegenerative Disease 35 96.36 Very High Very High Very High
Disease 90 94.40 High High
Cv General 4 Under Development 6 93.48 High High
Motor Neuron Diseases 3 92.68 High High
Adhesions 29 91.92 High High
Nervous System Malformation 28 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDK5/p25 was reconstituted by mixing equal amounts of recombinant human CDK5 and p25 expressed in E. coli as GST (Glutathione-S-transferase) fusion proteins and purified by affinity chromatography on glutathione-agarose (vectors kindly provided by Dr.
Gene_expression (expressed) of CDK5
1) Confidence 0.58 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0 Pain Relevance 0
The absence of p39 did not produce aberrant phenotype, indicating a predominant role of p35 in CDK5 activation [7].
Gene_expression (role) of CDK5
2) Confidence 0.46 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.62 Pain Relevance 0.19
In mouse, Cdk5 modulates PAK kinases and is implicated in actin reorganization, which may be critical for neuron migration along radial glia [3].
Gene_expression (modulates) of Cdk5 in neuron
3) Confidence 0.46 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.38 Pain Relevance 0.08
Hyperactivity of CDK5 mediated by p25, a proteolytic fragment of p35, has been implicated in the pathogenesis of several neurodegenerative disorders, such as Alzheimer's disease [14], Parkinson's disease [15] and amyotrophic lateral sclerosis [16].
Gene_expression (mediated) of CDK5 in lateral associated with disease, neurodegenerative disease, attention deficit hyperactivity disorder and motor neuron diseases
4) Confidence 0.46 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 1.07 Pain Relevance 0.13
We have recently provided evidence for a potential role of Cdk5/p35 in the response to ischaemic injury as we showed association of Cdk5 with nuclear damage, by demonstrating co-expression of Cdk5 in TUNEL-positive neurons following human stroke and in propidium iodide-positive human foetal neurons following OGD [37].
Gene_expression (expression) of Cdk5 in neurons associated with stroke and injury
5) Confidence 0.35 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.58 Pain Relevance 0
CCNA1 and CCNYL1 were upregulated 2 and 1.5 fold respectively, and expression of CCNF, CDK5 and CDK10 were suppressed, up to 2 fold for CDK10.
Gene_expression (expression) of CDK5
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.24 Pain Relevance 0.07
This data suggests that PAR2 regulates the cell cycle at the transcriptional level, modulating the expression of a number of important genes including crucial regulators of cell cycle transitions such as the cyclin family (CCNA1, CCNF, CCNYL1) and cyclin-dependent kinases (CDK5, CDK10).
Gene_expression (expression) of CDK5
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.25 Pain Relevance 0.11
P35/Cdk5 causes PAK1 hyperphosphorylation, which results in PAK1 down-regulation and is likely to have an impact on the dynamics of the reorganization of the actin cytoskeleton in neurons during dendrite development [36].
Gene_expression (causes) of Cdk5 in dendrite
8) Confidence 0.31 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.69 Pain Relevance 0.03
Results: We detected cdk5 and its activators, p35 and p39, in peripheral blood eosinophils.
Gene_expression (detected) of cdk5 in blood
9) Confidence 0.24 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.34 Pain Relevance 0.03
Methods: Western blotting, RT-PCR, and flow cytometry were used to determine the expression of cdk5, p35, and p39 in eosinophils obtained from atopic human donors.
Spec (determine) Gene_expression (expression) of cdk5 in eosinophils
10) Confidence 0.24 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.35 Pain Relevance 0.04
Objectives: To determine the expression of cdk5, and cdk5 activators (p35 and p39), and its role in eosinophil mediator release.
Spec (determine) Gene_expression (expression) of cdk5 in eosinophil
11) Confidence 0.24 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.36 Pain Relevance 0.04
Eosinophil cdk5 was shown to have functional kinase activity and express Munc 18c, a cdk5 substrate that directly regulates granule fusion.
Gene_expression (express) of cdk5 in Eosinophil
12) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.41 Pain Relevance 0.05
Objectives: To determine the expression of cdk5, and cdk5 activators (p35 and p39), and its role in eosinophil mediator release.
Spec (determine) Gene_expression (expression) of cdk5 in eosinophil
13) Confidence 0.11 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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