INT219360

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP11) extracellular region (MMP11) proteinaceous extracellular matrix (MMP11)
MMP11 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 54.36 Quite High
ischemia 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 25 98.16 Very High Very High Very High
Endometrial Cancer 153 97.32 Very High Very High Very High
Stroke 53 84.24 Quite High
Apoptosis 21 77.88 Quite High
Congenital Anomalies 2 70.92 Quite High
Aneuploidy 3 60.00 Quite High
Malignant Neoplastic Disease 18 58.72 Quite High
Adenocarcinoma 6 44.84 Quite Low
Endometrial Hyperplasia 4 44.12 Quite Low
Microsatellite Instability 47 36.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP11 mRNA and protein levels remained unchanged in HFN and HBMEC exposed to conditions of oxygen-glucose deprivation.


Neg (unchanged) Regulation (unchanged) of MMP11
1) Confidence 0.54 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.47 Pain Relevance 0.03
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Regulation (regulated) of MMP11 associated with endometrial cancer
2) Confidence 0.09 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.24 Pain Relevance 0

General Comments

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