INT219361

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2007
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.91
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAK1) Golgi apparatus (PAK1) plasma membrane (PAK1)
cytoplasm (PAK1)
Anatomy Link Frequency
brain 2
neuronal 1
neurons 1
PAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 32 99.60 Very High Very High Very High
Inflammation 16 83.36 Quite High
imagery 8 72.40 Quite High
ischemia 24 9.16 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 424 99.08 Very High Very High Very High
Middle Cerebral Artery Infarction 200 98.32 Very High Very High Very High
Cv Unclassified Under Development 72 97.82 Very High Very High Very High
Injury 16 88.88 High High
Cv General 4 Under Development 24 88.16 High High
INFLAMMATION 16 83.36 Quite High
Apoptosis 40 82.80 Quite High
Brain Injury 24 73.28 Quite High
Breast Cancer 8 66.64 Quite High
Pathologic Processes 8 56.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using Western blotting and immunohistochemistry, PAK1, INI1 and MMP11 protein expression and localization was determined in the contralateral and ipsilateral brain areas of individual stroke patients and rats subjected to MCAO, and in HBMEC and HFN exposed to OGD and reperfusion.


Gene_expression (expression) of PAK1 in brain associated with middle cerebral artery infarction and stroke
1) Confidence 0.75 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.45 Pain Relevance 0
Finally, an increase in PAK1 expression was also seen in human foetal neurons following oxygen-glucose deprivation (Figure 4Fi and 4Fii).


Gene_expression (expression) of PAK1 in neurons
2) Confidence 0.75 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.61 Pain Relevance 0
Here, we have reported for the first time an upregulation in PAK1 protein levels in human and rat brain samples following MCAO and in HFN following oxygen-glucose deprivation.
Gene_expression (levels) of PAK1 in brain associated with middle cerebral artery infarction
3) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.71 Pain Relevance 0
Filters were blocked in 1% w/v bovine serum albumin (BSA) in Tris-buffered saline Tween (TBS Tween) and stained overnight at 4°C with antibodies to the following proteins (obtained from Autogen Bioclear, Wiltshire, UK, unless stated otherwise) diluted in 1% BSA: MMP11 (CalBiochem; 1:500), PAK1 (1:500), INI1 (1:500), and ?
Neg (blocked) Gene_expression (blocked) of PAK1
4) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0 Pain Relevance 0.04
Filters were blocked in 1% w/v bovine serum albumin (BSA) in Tris-buffered saline Tween (TBS Tween) and stained overnight at 4°C with antibodies to the following proteins (obtained from Autogen Bioclear, Wiltshire, UK, unless stated otherwise) diluted in 1% BSA: MMP11 (CalBiochem; 1:500), PAK1 (1:500), INI1 (1:500), and ?
Gene_expression (1:500) of PAK1
5) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0 Pain Relevance 0.03
To test whether our microarray analysis could predict novel candidate genes involved in the cerebral response to ischaemia with possible functional importance and significance in stroke-induced neuronal damage, we measured protein expression and cellular localisation for three induced genes, INI1, PAK1 and MMP11.
Gene_expression (expression) of PAK1 in neuronal associated with stroke and cv unclassified under development
6) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.69 Pain Relevance 0.04
The expression of novel genes, including p21-activated kinase 1 (PAK1), matrix metalloproteinase 11 (MMP11) and integrase interactor 1, was further analyzed by RT-PCR, Western blotting and immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of PAK1 associated with metalloproteinase
7) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2194693 Disease Relevance 0.22 Pain Relevance 0.05
The expression of novel genes, including p21-activated kinase 1 (PAK1), matrix metalloproteinase 11 (MMP11) and integrase interactor 1, was further analyzed by RT-PCR, Western blotting and immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of p21-activated kinase 1 associated with metalloproteinase
8) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2194693 Disease Relevance 0.22 Pain Relevance 0.05

General Comments

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