INT219368

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAK1) Golgi apparatus (PAK1) plasma membrane (PAK1)
cytoplasm (PAK1)
Anatomy Link Frequency
middle cerebral artery 2
neuron 1
PAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 12 99.56 Very High Very High Very High
Inflammation 6 53.40 Quite High
ischemia 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 75 98.90 Very High Very High Very High
Injury 6 90.48 High High
Cv General 4 Under Development 9 79.56 Quite High
Stroke 159 79.12 Quite High
Cv Unclassified Under Development 27 65.68 Quite High
INFLAMMATION 6 53.40 Quite High
Apoptosis 15 52.84 Quite High
Breast Cancer 3 32.88 Quite Low
Pathologic Processes 3 22.72 Low Low
Wound Healing 3 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GAPDH: glyceraldehyde 3-phosphate dehydrogenase; HBMEC: human brain microvascular endothelial cells; HFN: human foetal neurons; INI1: integrase interactor 1; MCAO: middle cerebral artery occlusion; MMP11: matrix metalloproteinase; OGD: oxygen-glucose deprivation; PAK1: p21-activated kinase 1.


Negative_regulation (deprivation) of PAK1 in middle cerebral artery associated with middle cerebral artery infarction and metalloproteinase
1) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.20 Pain Relevance 0.05
GAPDH: glyceraldehyde 3-phosphate dehydrogenase; HBMEC: human brain microvascular endothelial cells; HFN: human foetal neurons; INI1: integrase interactor 1; MCAO: middle cerebral artery occlusion; MMP11: matrix metalloproteinase; OGD: oxygen-glucose deprivation; PAK1: p21-activated kinase 1.


Negative_regulation (deprivation) of p21-activated kinase 1 in middle cerebral artery associated with middle cerebral artery infarction and metalloproteinase
2) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.20 Pain Relevance 0.05
Based on this evidence, these authors proposed the existence of a neuron-specific signalling complex involving Cdk5/p35-PAK1 that inhibits PAK1 activity in neurons.
Negative_regulation (inhibits) of PAK1 in neuron
3) Confidence 0.41 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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