INT21937

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Context Info
Confidence 0.39
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 27
Disease Relevance 22.34
Pain Relevance 13.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Scly) cytoplasm (Scly)
Anatomy Link Frequency
finger 10
SAPS 1
sinus 1
Atrium 1
SNS 1
Scly (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 1476 100.00 Very High Very High Very High
lidocaine 30 99.82 Very High Very High Very High
Fibrositis 16 99.68 Very High Very High Very High
Pain 16 99.28 Very High Very High Very High
epidural 8 97.32 Very High Very High Very High
tetrodotoxin 3 94.40 High High
Autonomic response 2 87.88 High High
Biofeedback 4 85.40 High High
Action potential 3 83.44 Quite High
Face pain 1 81.00 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 1512 100.00 Very High Very High Very High
Fibromyalgia 7 99.68 Very High Very High Very High
Pain 13 99.28 Very High Very High Very High
Disorder Of Lipid Metabolism 108 99.16 Very High Very High Very High
Peripheral Arterial Disease 12 88.80 High High
Sleep Disorders 4 85.80 High High
Facial Neuralgia 1 81.36 Quite High
Autoimmune Disease 12 78.56 Quite High
Bruxism 1 75.00 Quite High
Stress 3 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pain stimulation produced a significant increase in SCL and a significant decrease in BF at both the antebrachium and brachium.
Positive_regulation (increase) of SCL associated with pain
1) Confidence 0.39 Published 2002 Journal Nurs Health Sci Section Abstract Doc Link 12153407 Disease Relevance 0.68 Pain Relevance 0.87
In the presence of ryanodine, cesium significantly decreased D1 (-39.3%), shifted the late diastolic potential more negative, and increased SCL (+25.7%).
Positive_regulation (increased) of SCL
2) Confidence 0.37 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.09
Ryanodine (10(-6) M) caused a small but significant initial decrease (-3.7%) followed by a progressive increase in SCL (+172%).
Positive_regulation (increase) of SCL
3) Confidence 0.37 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.11
Verapamil (0.4-1.0 microM) progressively increased SCL by decreasing late diastolic slope, resulting in oscillatory potentials and eventual quiescence.
Positive_regulation (increased) of SCL
4) Confidence 0.37 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.14
Furthermore, an increase of the SCL during the period of treatment was observed for both groups in session I and II, while session III produced nearly stable values.
Positive_regulation (increase) of SCL
5) Confidence 0.36 Published 2001 Journal J Oral Rehabil Section Abstract Doc Link 11580823 Disease Relevance 0.16 Pain Relevance 0.23
Sinus cycle length (SCL) and Atrium-His (AH) interval increased by 9 and 11 per cent respectively (P less than 0.05), 30 min after TEL.
Positive_regulation (increased) of SCL in Atrium associated with lidocaine
6) Confidence 0.29 Published 1990 Journal Can J Anaesth Section Abstract Doc Link 2225302 Disease Relevance 0 Pain Relevance 1.22
Intravenous lidocaine did not increase either SCL or AH.
Neg (not) Positive_regulation (increase) of SCL associated with lidocaine
7) Confidence 0.29 Published 1990 Journal Can J Anaesth Section Abstract Doc Link 2225302 Disease Relevance 0 Pain Relevance 1.25
E-4031 (0.1-3 micromol/kg i.v.) increased the sinus cycle length (SCL) and SNRT dose dependently.
Positive_regulation (increased) of SCL in sinus
8) Confidence 0.28 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9456272 Disease Relevance 0 Pain Relevance 0
When SAP stimulation increased SCL, SNRT, CSNRT, and SACT, E-4031 selectively inhibited the prolongation of SCL by SAP stimulation but did not affect the prolongation of CSNRT or SACT.
Positive_regulation (increased) of SCL
9) Confidence 0.28 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9456272 Disease Relevance 0 Pain Relevance 0
We observed significant asymmetries of SEMG level, TEMP and SCL in the FMS Group.
Positive_regulation (asymmetries) of SCL associated with fibrositis
10) Confidence 0.24 Published 2006 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 17063406 Disease Relevance 0.74 Pain Relevance 0.51
Considering that the geographic incidence of MScl indicates an increase in MScl with a decrease in sunlight exposure, that vitamin D is produced in the skin by solar or UV irradiation and that high serum levels of 25-hydroxyvitamin D have been reported to correlate with a reduced risk of MScl, a protective role of vitamin D has been suggested [32].
Positive_regulation (increase) of MScl in skin associated with multiple sclerosis
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.08 Pain Relevance 0.48
Another differentially abundant peptide was identified as a part apolipoprotein D, which has previously been shown to be elevated intrathecally in MScl patients [17].
Positive_regulation (elevated) of MScl associated with multiple sclerosis and disorder of lipid metabolism
12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.67 Pain Relevance 0.25
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis
13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.81 Pain Relevance 0.84
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.82 Pain Relevance 0.84
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.69 Pain Relevance 0.77
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis
16) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.67 Pain Relevance 0.76
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.87 Pain Relevance 0.87
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis
18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.85 Pain Relevance 0.86
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis
19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.84 Pain Relevance 0.85
Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).


Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis
20) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.82 Pain Relevance 0.84

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