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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.80
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5)
cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)
Anatomy Link Frequency
neuronal 1
eosinophil 1
CDK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 87.84 High High
Central nervous system 11 76.64 Quite High
Neuritis 1 71.08 Quite High
Spinal cord 1 7.36 Low Low
agonist 10 5.00 Very Low Very Low Very Low
complementary and alternative medicine 10 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 5 100.00 Very High Very High Very High
Neurodegenerative Disease 11 98.16 Very High Very High Very High
Motor Neuron Diseases 1 96.24 Very High Very High Very High
Cv General 4 Under Development 3 95.60 Very High Very High Very High
Disease 23 94.68 High High
Syndrome 6 89.04 High High
INFLAMMATION 33 87.84 High High
Intellectual Impairment 5 87.68 High High
Attention Deficit Hyperactivity Disorder 2 87.08 High High
Stroke 53 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, phosphorylated neurofilaments and their associated kinases, most of which are represented by CDK5, were found in protein aggregates typical of neurodegenerative diseases.
Localization (represented) of CDK5 associated with neurodegenerative disease
1) Confidence 0.52 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 1.36 Pain Relevance 0.11
B p65 and p50 were significantly enriched at predicted binding elements on promoter regions of MAPK1, CDK5, SLC2A1, IGF1R, TUBB, BRAF, DROSHA, ITGB4, MT1X and MT1E, when compared with the no antibody ChIP-qPCR control and the nonspecific occupancy at ACTB (Figure 3B, C and 3D).
Localization (occupancy) of CDK5
2) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
PAK1 is a downstream Rac effector and a major cyclin-dependent kinase 5 (Cdk5) substrate and target that co-localizes with p35/Cdk5 at neuronal peripheries.
Localization (localizes) of Cdk5 in neuronal
3) Confidence 0.34 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.65 Pain Relevance 0.03
Conclusions: Cdk5 is an important intracellular regulator of eosinophil adhesion to fibronectin and EPO secretion.
Localization (secretion) of Cdk5 in eosinophil associated with adhesions
4) Confidence 0.23 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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