INT219376

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.84
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAK1) Golgi apparatus (PAK1) plasma membrane (PAK1)
cytoplasm (PAK1)
Anatomy Link Frequency
dendrite 1
neuronal 1
neurons 1
brain 1
PAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 81.48 Quite High
metalloproteinase 32 67.20 Quite High
ischemia 24 31.96 Quite Low
anesthesia 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 424 99.96 Very High Very High Very High
Middle Cerebral Artery Infarction 200 97.72 Very High Very High Very High
Cv Unclassified Under Development 72 96.88 Very High Very High Very High
Cv General 4 Under Development 24 91.68 High High
Injury 16 89.52 High High
Breast Cancer 8 85.36 High High
INFLAMMATION 16 81.48 Quite High
Apoptosis 40 80.92 Quite High
Pathologic Processes 8 75.20 Quite High
Wound Healing 8 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although in the animal model PAK1 protein levels returned to normal 3 days following stroke, some patients showed elevated levels for PAK1 at later time-points too.
Positive_regulation (elevated) of PAK1 associated with stroke
1) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.84 Pain Relevance 0.03
Western blotting showed an upregulation in the protein levels of PAK1 in 6 of 12 patients (Table 4; Figure 4Bi and 4Bii).
Positive_regulation (upregulation) of PAK1
2) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.49 Pain Relevance 0
PAK1 was only induced in the human study although present in both microarray sets, MMP11 was induced in both cases, while INI1 was induced in the human but was not present in the rat microarray set.
Positive_regulation (induced) of PAK1
3) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.36 Pain Relevance 0
RT-PCR confirmed the upregulation of pak1 determined by the microarrays in pooled samples from stroke patients who survived between 2 and 6 days following stroke (Figure 4A).
Positive_regulation (upregulation) of pak1 associated with stroke
4) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.49 Pain Relevance 0
P35/Cdk5 causes PAK1 hyperphosphorylation, which results in PAK1 down-regulation and is likely to have an impact on the dynamics of the reorganization of the actin cytoskeleton in neurons during dendrite development [36].
Positive_regulation (results) of PAK1 in dendrite
5) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.69 Pain Relevance 0.03
To test whether our microarray analysis could predict novel candidate genes involved in the cerebral response to ischaemia with possible functional importance and significance in stroke-induced neuronal damage, we measured protein expression and cellular localisation for three induced genes, INI1, PAK1 and MMP11.
Positive_regulation (induced) of PAK1 in neuronal associated with stroke and cv unclassified under development
6) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.68 Pain Relevance 0.04
In patients surviving for 3 days to 4 weeks after stroke, increased PAK1 nuclear staining was seen in neurons in both peri-infarcted and infarcted regions (Figure 4Dii).
Positive_regulation (increased) of PAK1 in neurons associated with stroke
7) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.60 Pain Relevance 0
Here, we have reported for the first time an upregulation in PAK1 protein levels in human and rat brain samples following MCAO and in HFN following oxygen-glucose deprivation.
Positive_regulation (upregulation) of PAK1 in brain associated with middle cerebral artery infarction
8) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.71 Pain Relevance 0

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