INT21938

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Context Info
Confidence 0.10
First Reported 1982
Last Reported 1995
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 11.33
Pain Relevance 7.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp7b) Golgi apparatus (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
plasma 8
lymph 1
chest 1
platelet 1
body 1
Atp7b (Mus musculus)
Pain Link Frequency Relevance Heat
beta blocker 4 99.98 Very High Very High Very High
Serotonin 19 99.76 Very High Very High Very High
depression 4 99.76 Very High Very High Very High
anesthesia 26 99.64 Very High Very High Very High
Restless leg syndrome 6 99.60 Very High Very High Very High
epidural 8 99.20 Very High Very High Very High
Angina 16 99.10 Very High Very High Very High
Regional anesthesia 2 97.96 Very High Very High Very High
local anesthetic 4 96.44 Very High Very High Very High
cva 10 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Burns 9 99.86 Very High Very High Very High
Depression 4 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 14 99.60 Very High Very High Very High
Stroke 15 99.32 Very High Very High Very High
Bacteremia 12 99.32 Very High Very High Very High
Bacterial Respiratory Disease 6 99.28 Very High Very High Very High
Angina 5 99.10 Very High Very High Very High
Sepsis 15 98.92 Very High Very High Very High
Cancer 4 97.48 Very High Very High Very High
Disease 15 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BA TxB2 rose from 40 per cent to 132 per cent of control during and after pacing, but was absent after 10 min (p less than 0.05).
Positive_regulation (absent) of TxB2
1) Confidence 0.10 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6407435 Disease Relevance 1.01 Pain Relevance 0.74
Plasma TxB2 levels also remained elevated 1 h after anesthesia.
Positive_regulation (elevated) of TxB2 in Plasma associated with anesthesia
2) Confidence 0.07 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0 Pain Relevance 0.84
Plasma TxB2 level was markedly elevated in bypass operation when synthetic prosthesis were used.
Positive_regulation (elevated) of TxB2 in Plasma
3) Confidence 0.07 Published 1985 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 2935731 Disease Relevance 0.69 Pain Relevance 0.09
The factors which are considered to be related to elevation of plasma TxB2 level during the operation and the postoperative period are as follows: a) surgical intervention, b) anesthesia, c) thromboembolic complication, d) grafting of synthetic prosthesis. e) valve replacement and f) cardiopulmonary bypass.
Positive_regulation (elevation) of TxB2 in plasma associated with anesthesia and cva
4) Confidence 0.07 Published 1985 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 2935731 Disease Relevance 0.65 Pain Relevance 0.14
TxB is increased early in graded bacterial sepsis.
Positive_regulation (increased) of TxB associated with sepsis
5) Confidence 0.07 Published 1984 Journal J Trauma Section Abstract Doc Link 6481830 Disease Relevance 0.44 Pain Relevance 0
TxB was increased from control at 20 minutes, rising to four times control at 120 minutes.
Positive_regulation (increased) of TxB
6) Confidence 0.06 Published 1984 Journal J Trauma Section Abstract Doc Link 6481830 Disease Relevance 0.36 Pain Relevance 0.07
TxB elevations led the cross-correlated variables by 0 to 60 minutes.
Positive_regulation (elevations) of TxB
7) Confidence 0.06 Published 1984 Journal J Trauma Section Abstract Doc Link 6481830 Disease Relevance 0.49 Pain Relevance 0.05
The results suggest that the increased TxB2 plasma levels and platelet TxB2 production during regional anesthesia are not caused by local anesthetics itself but by other factors, e.g. tissue trauma.
Positive_regulation (increased) of TxB2 in platelet associated with injury, regional anesthesia and local anesthetic
8) Confidence 0.04 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0.09 Pain Relevance 0.98
In cardiopulmonary bypass, TxB2 level were markedly elevated ten minutes after beginning, and then decreased gradually until the end of cardiopulmonary bypass.
Positive_regulation (elevated) of TxB2
9) Confidence 0.04 Published 1985 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 2935731 Disease Relevance 0.68 Pain Relevance 0.12
Plasma TxB2 values during operation and immediate period after operation were significantly elevated compared with preoperative values.
Positive_regulation (elevated) of TxB2 in Plasma
10) Confidence 0.04 Published 1985 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 2935731 Disease Relevance 0.69 Pain Relevance 0.08
The elevated TxB2 concentrations during and after surgery can be regarded, in some patients, as a potential risk factor for cardiovascular and thromboembolic complications.
Positive_regulation (elevated) of TxB2 associated with cva
11) Confidence 0.02 Published 1987 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3478740 Disease Relevance 0.16 Pain Relevance 0.16
Patients without chest pain or without ST-segment depression moderately increased (p less than 0.05) their urinary Tx-M (by 21% and 13%, respectively) and PGI-M (by 28% and 23%, respectively) after exercise.
Positive_regulation (increased) of Tx-M in chest associated with angina and depression
12) Confidence 0.02 Published 1990 Journal Circulation Section Abstract Doc Link 2225375 Disease Relevance 0.89 Pain Relevance 0.59
After operation, TxB2 concentrations remained elevated but the other prostanoids returned to preoperative values.
Positive_regulation (elevated) of TxB2
13) Confidence 0.02 Published 1987 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3478740 Disease Relevance 0.07 Pain Relevance 0.16
The bicycle test induced a significant increase in serum TxB2 in patients without treatment and during verapamil therapy.
Positive_regulation (increase) of TxB2
14) Confidence 0.01 Published 1985 Journal Thromb. Res. Section Abstract Doc Link 4038824 Disease Relevance 0.16 Pain Relevance 0.16
Urinary dinor-metabolites of TxB2 and PGI2 (Tx-M and PGI-M, respectively) were estimated by gas chromatography/negative ion-chemical ionization mass spectrometry in samples collected prior to, during and immediately after 20 min of severe treadmill exertion.
Positive_regulation (dinor-metabolites) of Tx-M
15) Confidence 0.01 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.54 Pain Relevance 0.31
Urinary dinor-metabolites of TxB2 and PGI2 (Tx-M and PGI-M, respectively) were estimated by gas chromatography/negative ion-chemical ionization mass spectrometry in samples collected prior to, during and immediately after 20 min of severe treadmill exertion.
Positive_regulation (dinor-metabolites) of TxB2
16) Confidence 0.01 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.54 Pain Relevance 0.30
Although indomethacin blocked the NaF-induced increase in plasma TxB2 concentration, the cyclooxygenase inhibitor did not modify any cardiopulmonary parameter measured or calculated, except for a transient reduction in PVR at 2.5 h.
Positive_regulation (increase) of TxB2 in plasma
17) Confidence 0.01 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7759426 Disease Relevance 0 Pain Relevance 0
PGE2 and TxB2 are released in large quantities and are increased after stimulation with zymosan.
Positive_regulation (increased) of TxB2
18) Confidence 0.01 Published 1982 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 7123126 Disease Relevance 0.30 Pain Relevance 0.10
TxB is increased early in graded bacteremia and appears related to cardiorespiratory dysfunction.
Positive_regulation (increased) of TxB associated with bacteremia
19) Confidence 0.01 Published 1985 Journal Circ. Shock Section Abstract Doc Link 3915237 Disease Relevance 0.48 Pain Relevance 0.05
TxB was significantly increased at 30 min and remained elevated thereafter.
Positive_regulation (elevated) of TxB
20) Confidence 0.01 Published 1985 Journal Circ. Shock Section Abstract Doc Link 3915237 Disease Relevance 0.54 Pain Relevance 0.07

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