INT21940

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 17.42
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
Bowel 1
eggs 1
kidney 1
reticulum 1
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 10 96.64 Very High Very High Very High
Causalgia 1 89.76 High High
Rsd 2 89.16 High High
allodynia 2 81.48 Quite High
tolerance 3 79.56 Quite High
Paracetamol 1 76.32 Quite High
metalloproteinase 2 70.96 Quite High
imagery 8 66.64 Quite High
Bioavailability 2 59.48 Quite High
Pain threshold 2 59.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 277 100.00 Very High Very High Very High
Stress 160 100.00 Very High Very High Very High
Apoptosis 56 100.00 Very High Very High Very High
Infection 258 99.88 Very High Very High Very High
Hookworm Infection 116 99.86 Very High Very High Very High
Nicotine Addiction 62 99.84 Very High Very High Very High
Rectal Cancer 10 99.80 Very High Very High Very High
Chondrosarcoma 12 99.42 Very High Very High Very High
Ascariasis 44 98.96 Very High Very High Very High
Trichuriasis 40 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SSA obtained from the affected side was significantly increased compared with that from the normal (right) side.
Positive_regulation (increased) of SSA
1) Confidence 0.40 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2225664 Disease Relevance 1.11 Pain Relevance 0.53
Induction of the endoplasmic reticulum stress proteins GRP78, GRP94, calreticulin and protein disulfide isomerase was assessed by immunoblotting.
Positive_regulation (Induction) of calreticulin in reticulum associated with stress
2) Confidence 0.39 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15049342 Disease Relevance 0.59 Pain Relevance 0.12
Moreover, in both COS-7 and RCS cells, shRNA 3B reduced the elevated CRT levels that result from the overexpression of COMP.
Positive_regulation (elevated) of CRT associated with chondrosarcoma
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.36 Pain Relevance 0
For example, several UPR proteins, including BiP and calreticulin, were found to be up-regulated in smokers.
Positive_regulation (up) of calreticulin associated with nicotine addiction
4) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.42 Pain Relevance 0
For example, several UPR proteins, including BiP and calreticulin, were found to be up-regulated in smokers.
Positive_regulation (regulated) of calreticulin associated with nicotine addiction
5) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.43 Pain Relevance 0
A phase I trial was conducted of erlotinib CRT with gemcitabine followed by maintenance erlotinib for locally advanced pancreatic cancer.90 A retrospective study of single-agent erlotinib as second-line therapy showed no observed responses.91 Second-line erlotinib with capecitabine in gemcitabine refractory pancreatic cancer showed a modest median survival time of 6.5 months and a RR of 10%.92

Cetuximab: limited activity

Positive_regulation (conducted) of CRT associated with pancreatic cancer
6) Confidence 0.15 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.62 Pain Relevance 0
The French 2000–2001 Fédération Francophone de la Cancéologie Digestive/Société Française de Radiothérapie Oncologie (FFCD/SFRO) study was a phase III trial comparing intensive induction CRT (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer.
Positive_regulation (induction) of CRT associated with pancreatic cancer
7) Confidence 0.15 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.71 Pain Relevance 0
These observations may reflect the ability of Ascaris and Trichuris eggs to survive in urban environments, so that increased urbanization in SSA may promote emergence of ascariasis and trichuriasis in the future.


Positive_regulation (increased) of SSA in eggs associated with trichuriasis and ascariasis
8) Confidence 0.12 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.34 Pain Relevance 0
Three randomized phase III studies, STAR-01 (primary objective: overall survival), ACCORD 12/0405 PRODIGE 2 (primary objective: pathological complete response) and National Surgical Adjuvant Breast and Bowel Project (NSABP) R-04, have been conducted to study the role of oxaliplatin in the neoadjuvant CRT for LARC.
Positive_regulation (neoadjuvant) of CRT in Bowel associated with rectal cancer
9) Confidence 0.08 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2856525 Disease Relevance 0.79 Pain Relevance 0
It is known to be endemic in Zimbabwe and South Africa, although based on serologic surveys the infection also occurs elsewhere in SSA [125],[126].
Positive_regulation (occurs) of SSA associated with infection
10) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.34 Pain Relevance 0
Approximately one-third of the world's hookworm today occurs in SSA (Table 2) [3], with the greatest number of cases occurring in Nigeria (38 million) and the Democratic Republic of Congo (DRC, 31 million), followed by Angola, Ethiopia, and Cote d'Ivoire (10–11 million) (Table 3).
Positive_regulation (occurs) of SSA associated with hookworm infection
11) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 1.26 Pain Relevance 0
Since the global prevalence of STH infections was first estimated by Stoll over 60 years ago [31], the overall prevalence of the STH infections is believed to have remained relatively constant in SSA, whereas it has diminished elsewhere in the developing world [24].
Positive_regulation (constant) of SSA associated with infection
12) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.20 Pain Relevance 0
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Positive_regulation (/) of Crt in kidney
13) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.49 Pain Relevance 0.03
Patients with >50% reduction of GH secretion after treatment with lanreotide were considered as SSA responders, while patients with <50% GH secretion were considered as SSA nonresponders [16].
Positive_regulation (responders) of SSA
14) Confidence 0.04 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.69 Pain Relevance 0.11
The GH-lowering effect of SSA is positively correlated with the level of sst2 mRNA expression [27-29].
Positive_regulation (effect) of SSA
15) Confidence 0.04 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.09 Pain Relevance 0.16
In this study we demonstrated that both SSa and SSd potently sensitize a number of human cancer cells to cisplatin-induced apoptosis through ROS accumulation.
Positive_regulation (accumulation) of SSa associated with cancer and apoptosis
16) Confidence 0.04 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.99 Pain Relevance 0

General Comments

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