INT219405

Context Info Confidence 0.20 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.11 Pain Relevance 0

cytoplasm (CCNF, PCNA) nucleus (CCNF, PCNA) nucleoplasm (PCNA) DNA binding (PCNA) cell proliferation (PCNA) mitosis (CCNF)

CCNF (Homo sapiens) PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 5.00 Neurotransmitter 1 5.00 Pain 1 5.00 Dismenorea 1 5.00 Dopamine 1 5.00 Rheumatism 1 5.00 nud 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 30 57.68 Stress 30 52.20 Breast Cancer 11 50.00 Hypoxia 17 5.00 Cancer 7 5.00 Adenocarcinoma 3 5.00 Metastasis 2 5.00 Hyperplasia 2 5.00 Starvation 2 5.00 Hepatocellular Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Genes, whose products are involved in the transition from G1 to S-phase appeared to be downregulated, such as cyclins (CCNA2, CCNE2, CCNF), cyclin-dependent kinase 2 (CDK2) and transcription regulators (E2F2, PCNA, SKP2), whereas transcription of inhibitory genes cyclin G2 (CCNG2), GADD45A (growth arrest and DNA-damage-inducible, alpha) and p21cip1 (cyclin-dependent kinase inhibitor 1A, CDKN1A) was increased.

CCNF Regulation (regulators) of PCNA

1) Confidence 0.20 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.11 Pain Relevance 0

General Comments

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