INT21941

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Context Info
Confidence 0.53
First Reported 1990
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.88
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
arm 1
sympathetic 1
pectoral fin 1
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain threshold 2 99.80 Very High Very High Very High
fluoxetine 20 99.52 Very High Very High Very High
allodynia 2 88.12 High High
sSRI 4 80.28 Quite High
Rsd 2 75.00 Quite High
Serotonin 4 73.92 Quite High
Causalgia 1 65.04 Quite High
drug abuse 1 63.16 Quite High
alcohol 1 60.80 Quite High
cINOD 4 37.56 Quite Low
Disease Link Frequency Relevance Heat
Pain 47 99.80 Very High Very High Very High
Kyphosis 4 98.92 Very High Very High Very High
Pressure And Volume Under Development 4 98.54 Very High Very High Very High
Aging 9 98.40 Very High Very High Very High
Skin Appendage Disease 2 98.34 Very High Very High Very High
Metastasis 22 97.24 Very High Very High Very High
Pancreatic Cancer 120 94.96 High High
Recurrence 8 92.68 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 28 91.60 High High
Neuropathic Pain 2 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excessive sympathetic out flow to the skin is considered to be the cause of palmar hyperhidrosis, swelling with redness, and lowered pain threshold, since pain threshold is under regulation of SSA.
Regulation (regulation) of SSA in sympathetic associated with pressure and volume under development, skin appendage disease and pain threshold
1) Confidence 0.53 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2225664 Disease Relevance 1.08 Pain Relevance 0.55
Role of gemcitabine in CRT
Regulation (Role) of CRT
2) Confidence 0.18 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.74 Pain Relevance 0
The estimated 5-year survival rate was 10% among patients assigned to receive CRT and 20% among patients who did not receive CRT (P = 0.05).18 However, this study may have suffered from selection bias and an insufficient sample size for a 2 × 2 study design.19 In addition, there was an excessive rate of local recurrence in the CRT arm, suggesting the radiation schedule was suboptimal.20

Outside the United States, adjuvant chemotherapy remains the focus of trials

Neg (not) Regulation (receive) of CRT in arm associated with recurrence
3) Confidence 0.13 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.18 Pain Relevance 0
Moreover, no significant changes in SSA and SACS angles were observed between postoperative values and those measured at follow-up, suggesting that the correction obtained with surgery was maintained, even on long-term follow-up.
Neg (no) Regulation (changes) of SSA
4) Confidence 0.11 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896578 Disease Relevance 0.99 Pain Relevance 0
Although SSA was significantly affected 24 h after fluoxetine exposure, there was little or no effect on pectoral fin movement.
Regulation (affected) of SSA in pectoral fin associated with fluoxetine
5) Confidence 0.03 Published 2007 Journal Neurotoxicol Teratol Section Abstract Doc Link 17761399 Disease Relevance 0.07 Pain Relevance 0.73
From 1-3 dpf, there was no effect on SSA or earlier stages of motor development, i.e., spontaneous coiling, evoked coiling and burst swimming.
Neg (no) Regulation (effect) of SSA
6) Confidence 0.03 Published 2007 Journal Neurotoxicol Teratol Section Abstract Doc Link 17761399 Disease Relevance 0.07 Pain Relevance 0.62
Despite the evident need to understand issues that affect older people in SSA, relative to other demographic trends, ageing in Africa has only recently started receiving attention in research and policy-making.
Regulation (affect) of SSA associated with aging
7) Confidence 0.01 Published 2010 Journal Global Health Action Section Body Doc Link PMC2957141 Disease Relevance 0.73 Pain Relevance 0.06

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